Acute Pain Modulation in the Central Nervous System: A Chronological Review

  • M. Tiengo
  • C. Benedetti


The objective of this presentation is to trace a short historical and philosophical chronology on the neuronal and neurochemical systems that, in the spinal cord and in the brain, modulate the nociceptive information caused by an algogenic stimulus.


Postoperative Pain Noxious Stimulus Nociceptive Information Preemptive Analgesia Central Gray Matter 
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  1. 1.
    Tiengo M (1994) Dolore, analgesia endogena ed il sistema della coscienza. Seminari sul dolore. Ed Mattioli, Parma, voi m;2:3–7Google Scholar
  2. 2.
    Melzack R (1961) The perception of pain. Sci Am 204:41–49PubMedCrossRefGoogle Scholar
  3. 3.
    Melzack R, Casev KL (1868) Sensory, motivational and central control determinants of pain. A new conceptual model. In: Kenshalol D (ed) The skin senses. Thomas, SpringfieldGoogle Scholar
  4. 4.
    Yeager MP, Glass DD, Neff RK, Bronk-Johnson T (1987) Epidural anesthesia and analgesia in high risk surgical patients. Anesthesiology 66:729–736PubMedCrossRefGoogle Scholar
  5. 5.
    Truman KJ, McCarthy RJ, March RJ et al (1991) Effects of epidural anesthesia and analgesia on coagulation and outcome after major vascular surgery. Anesth Analg 73:696–704Google Scholar
  6. 6.
    Zimmerman M (1995) Fisiopatologia del dolore. In: M Tiengo e M Zoppi, Guarire dal dolore, Biblioteca Universale Rizzoh, BUR, Milano, pp 11–62Google Scholar
  7. 7.
    Melzack R, Wall P (1965) Pain mechanism: a new theory Science 150:971–978Google Scholar
  8. 8.
    Muller J (1837) Handbuch der Physiology des Menschen für Vorlesungen. In: Buch V, Von den Sinnen, VV Abschmtt. Von Gefühlssinn, Verlag J Hoschler, Coblenz, pp 494–502Google Scholar
  9. 9.
    Von Frey Max (1896) Untersuchungen über der Menschlichen Haut. Erste Abhandlung Druckempfmdung und Schmerz, N° III, S Hirzel, LeipzigGoogle Scholar
  10. 10.
    Sherrington CS (1906) The integrative action of the nervous system. Scribner, New YorkGoogle Scholar
  11. 11.
    Sherrington CS (1898) Decerebrate rigidity and reflex co-ordination of movements. J Physiol 17–211Google Scholar
  12. 12.
    Eccles JC, Sherrington CS (1931) Studies on the flexor reflex, IV. Inhibition. Proc Roy Soc 109, 91CrossRefGoogle Scholar
  13. 13.
    Magoun HV (1944) Bulbar inhibition and facilitation of motor activity. Science 100:540–550CrossRefGoogle Scholar
  14. 14.
    Moruzzi G, Magoun HV (1949) Brain stem reticular formation and activation of EEG, electroenceph. Clin Neurophysiol 1;455Google Scholar
  15. 15.
    Hagbarth KE, Kerr DIB (1954) Central influence on spinal afferent conduction. J Neurophysiol 17:295–307PubMedGoogle Scholar
  16. 16.
    Melzack R, Stotler WA, Livingston WK (1958) Effects of discrete brain stem lesions in cats on perception of noxious stimulation. J Neurophysiol 21:353–357PubMedGoogle Scholar
  17. 17.
    Reynolds DV (1968) Surgery in the rat during electrical analgesia induced by focal brain stimulation. Science 164:444–5CrossRefGoogle Scholar
  18. 18.
    Mayer DJ, Wolfe TL, Akil H, Carder B, Liebeskind JC (1971) Analgesia from electrical simulation in the brain stem of the rat. Science 174:1351–1354PubMedCrossRefGoogle Scholar
  19. 19.
    Mayer DJ, Liebeskind JJ (1974) Pain reduction by focal electrical stimulation of the brain: an anatomical and behavioral analysis. Brain Res 68:73–93PubMedCrossRefGoogle Scholar
  20. 20.
    Oliveras GL, Guilbaud G, Besson JM, Liebeskind JC (1974) Behavioral and electrophysiological evidence of pain inhibition from midbrain stimulation in the cat. Exp Brain Res 20:32–44PubMedCrossRefGoogle Scholar
  21. 21.
    Basbaum A, Fields H (1978) Endogenous pain control mechanisms: review and hypothesis. Ann Neurol 4:451–462PubMedCrossRefGoogle Scholar
  22. 22.
    Bonica J (1981) Achievements of the past and challenge of the future. In: Bonica JJ, Lindbolm U, Iggo A (eds) Proceedings of the Third World Congress on Pain, Advances in Pain Research, vol 5, EdinburghGoogle Scholar
  23. 23.
    Basbaum A, Fields H (1996) Meccanismi del Sistema Nervoso Centrale della modulazione del dolore. Masson. In: M Tiengo, C Benedetti (eds) Fisiopatologia e Terapia del DoloreGoogle Scholar
  24. 24.
    Tiengo M, Agnati LE, Zimmermann M (1991) Pain and analgesia: a homeostatic system. Clin J Pain 7 [Suppl 1]Google Scholar
  25. 25.
    Jones E, Powell TPS (1973) Anatomical organization of the somatosensory cortex. In: Iggo A (ed) Handbook of sensory physiology, somatosensory system, vol 2. Springer, Berlin Heidelberg New York, pp 579–620Google Scholar
  26. 26.
    Willis WD (1985) The pain system. Karger, BaselGoogle Scholar
  27. 27.
    Cañavero S, Pagni CA et al (1993) The role of cortex in central pain syndromes: preliminary results of a long-term technetium-99 hexamethylpropylenaminexima single photon emission computed tomography study. Neurosurgery 185–191Google Scholar
  28. 28.
    Adams RD, Victor M (1989) Principle of neurosurgery. Mc Graw Hill, New YorkGoogle Scholar
  29. 29.
    Tiengo M (1995) So human the pain. Pathos 2,1:7–8Google Scholar
  30. 30.
    Changeux J-P, Connes A (1989) Matière à Pensée (ed) Odile Jacob, ParisGoogle Scholar
  31. 31.
    Eccles J (1991) I meccanismi della percezione del dolore: dai recettori sensoriali, alla corteccia cerebrale e da questa alla mente. Seminari sul dolore, 2:5–26Google Scholar
  32. 32.
    Eccles J (1994) Come l’io controlla il suo cervello. Rizzoh, MilanoGoogle Scholar
  33. 33.
    Crile GW (1910) Anoci-association. Saunders, PhiladelphiaGoogle Scholar
  34. 34.
    Bonica JJ (1953) The management of pain. Lea and Febiger, Philadelphia, pp 1240–244Google Scholar
  35. 35.
    Morpurgo CV, Spinelli DN (1976) Plasticity of pain perception. Brain Theory. 2:14–15 (newsletter)Google Scholar
  36. 36.
    Morpurgo CV, Spinelli DN (1976) Meccanismo di percezione del dolore: una nuova ipotesi. Anestesia e Rianimazione, 17, 2, pp 133–39Google Scholar
  37. 37.
    Morpurgo CV (1979) The role of cerebral cortex in the pain of cancer. In: Bonica JJ (ed) Advances in pain research and therapy. Raven, New York, pp 77–80Google Scholar
  38. 38.
    Woolf CJ (1983) Evidence for a central component of post-injury pain hypersensitivity. Nature, 306, pp 686–88PubMedCrossRefGoogle Scholar
  39. 39.
    Wall PD (1988) Editorial: the prevention of postoperative pain. Pain 33:289–290PubMedCrossRefGoogle Scholar
  40. 40.
    Dubner R (1991) Neuronal plasticity and pain following peripheral tissue inflammation on nerve injury. Proceedings of the VIth World Congress on Pain, pp 263–276Google Scholar
  41. 41.
    Cook AJ, Woolf CJ, McMahon SB (1987) Expansion of cutaneous receptive fields of dorsal hom neurones following C-primary afferent fibre inputs. Nature 325:151–53PubMedCrossRefGoogle Scholar
  42. 42.
    Bach S, Noreng MF, Tjeliden NU (1988) Phantom limb pain in amputees during the first 12 months following limb amputation, after preoperative lumbar epidural blockade. Pain 33: 297–301PubMedCrossRefGoogle Scholar
  43. 43.
    McQuay HJ, Carroll D, Moore RA (1988) Postoperative orthopedic pain the effect of opiate premedication and local anesthetic blocks. Pain 33:291–95PubMedCrossRefGoogle Scholar
  44. 44.
    Rice LS, Pudimat MA, Hannallack RS (1990) Timing of caudal block placement in relation to surgery does not affect duration of postoperative analgesia in paediatric ambulatory patients. Br J Anaesth 70:434–439Google Scholar
  45. 45.
    Dierking G, Dahl JB, Kanstrup J, Dahl AA, Kehiet H (1992) The effect of preversus postoperative inguinal field block on postoperative pain after hemiotomy. Br J Anaesth 68: 344–348PubMedCrossRefGoogle Scholar
  46. 46.
    Gustafsson I, Nystrom E, Quiding H (1983) Effect of preoperative paracetamol on pain after oral surgery. Eur J Clin Pharmacol 24:63–65PubMedCrossRefGoogle Scholar
  47. 47.
    Sisk AL, Mosley RO, Martin RP (1989) Comparison of preoperative and postoperative diflunisal for suppression of postoperative pain. J Oral Maxillofac Surg 4;7:464–468CrossRefGoogle Scholar
  48. 48.
    Murphy DF, Medley C (1993) Preoperative indomethacin for pain relief after thoracotomy: Comparison with postoperative indomethacin. Br J Anesth 70:298–300CrossRefGoogle Scholar
  49. 49.
    Tverskoy M, Cozacov C, Ayache M, Bradley Jr EL, Kissin I (1990) Postoperative pain after inguinal hereniorraphy with different types of anesthesia. Anesth Analg 70:29–35PubMedCrossRefGoogle Scholar
  50. 50.
    Jebeles JA, Reilly JS, Gutierrez JR, Bradley Jr EL, Kissin I (1991) The effect of pre-incisional infiltration of tonsils with bupivacaine on the pain following tonsillectomy under general anesthesia. Pain 47:305–308PubMedCrossRefGoogle Scholar
  51. 51.
    Katz J, Kavanagh H, Sandier AN, Nierenberg H, Boylan JF, Friedlander M, Shaw BF (1992) Preemptive analgesia: Clinical evidence of neuroplasticity contributing to postoperative pain. Anesthesiology 77:739–746CrossRefGoogle Scholar
  52. 52.
    Shir Y, Raja SN, Frank SM (1994) The effect of epidural versus general anesthesia on postoperative pain and analgesic requirements in patients undergoing radical prostatectomy. Anesthesiology 80; 1:49–56PubMedCrossRefGoogle Scholar
  53. 53.
    Dahl JB, Kehiet H (1993) The value of pre-emptive analgesia in the treatment of postoperative pain. Br J Anaesth 70:434–439PubMedCrossRefGoogle Scholar
  54. 54.
    Benedetti C (1990) Acute pain: a review of its effects and therapy with systemic opioids. In: Benedetti C, Chapman CR, Giron G (eds) Advances in pain research and therapy. Raven, New York, pp 367–424Google Scholar

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© Springer-Verlag Italia, Milano 1996

Authors and Affiliations

  • M. Tiengo
  • C. Benedetti

There are no affiliations available

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