Abstract
An antioxidant is defined as any substance which delays or prevents the oxidation of a substrate when it is present in small amounts relative to the amount of the substrate itself. Antioxidants are active at several levels of the oxidative sequence and their mechanism of action may be unique.
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References
Lefer AM, Araki H, Okamatsu S (1981) Beneficial actions of a free radical scavenger in traumatic shock and myocardial ischemia. Circ Shock 8:273–282
Novelli GP, De Gaudio AR (1983) Oxygen free-radicals in shock states. Elsevier, Amsterdam
De Gaudio AR, Sarti A, Palmarini M et al (1983) Prevenzione dello shock sperimentale mediante uno scavenger di radicali liberi: il glutatione ridotto. Acta Anaesth Ital 34:501–507
Saez JC, Ward PH, Gunther B et al (1984) Superoxide radical involvement in the pathogenesis of burn shock. Circ Shock 12:229–233
Novelh GP (1992) Oxygen radicals in experimental shock: effects of spin-trapping nitrones in ameliorating shock pathophysiology. Crit Care Med 20:499–507
Novelh GP, Angiolini P, Tani R et al (1985) Phenyl-t-butyl-nitrone is active against traumatic shock in rats. Free Radic Res Commun 1:321–327
Goode HF, Webster NR (1993) Free radicals and antioxidants in sepsis. Crit Care Med 21: 1770–1776
Schiller HJ, Reilly PM, Bulkley GB (1993) Antioxidant therapy. Crit Care Med 21:S92–102
Rice-Evans CA, Diplock AT (1993) Current status of antioxidant therapy. Free Radic Biol Med 15:77–96
Bone RC (1992) Inhibitors of complement and neutrophils: a critical evaluation of their role in the treatment of sepsis. Crit Care Med 20:891–898
Youn YK, Lalonde C, Demling R (1991) Use of antioxidant therapy in shock and trauma. Circ Shock 35:245–249
Mannion D, Fitzpatrick GJ, Feeley M (1994) Role of xanthine oxidase inhibition in survival from hemorrhagic shock. Circ Shock 42:39–43
Sahm AS (1991) Protection against stress-induced acute gastric mucosal injury by free-radical scavengers. Intensive Care Med 17:455–460
Tani T, Aoki H, Yoshioka T (1993) Treatment of septic shock with a protease inhibitor in a canine model: a prospective, randomized, controlled trial. Crit Care Med 21:925–930
Novelli GP, Innocenti P, Livi P (1993) II gabesato mesilato (Foy) nuovo antiproteasico sintetico nel trattamento dello shock. Studio multicentrico italiano. Minerva Anestesiol 58: 247–253
Novelh GP, Casali R, Bonizzoh M et al (1995) Azione antiossidante del gabesato mesilato (Foy) in un modello sperimentale di shock. Minerva Anestesiol 60 (in press)
Sanfey H, Bulkley GB, Cameron JL (1985) The pathogenesis of acute pancreatitis. The source and the role of oxygen-derived free radicals in three different experimental models. Ann Surg 201:633–639
Fujishima S, Aikawa N (1995) Neutrophil-mediated tissue injury and its modulation. Intensive Care Med 21:277–285
Wolbarsht ML, Fridovich I (1989) Hyperoxia during reperfusion is a factor in reperfusion injury. Free Radic Biol Med 6:61–62
Drugas GT, Paidas CN, Yahanda AM et al (1991) Conjugated desferoxamine attenuates hepatic microvascular injury following ischemia-reperfusion. Circ Shock 34:278–283
Fleckenstein AE, Smith SL, Linseman KL et al (1991) Comparison of the efficacy of mechanistically different antioxidants in the rat hemorrhagic shock model. Circ Shock 35: 223–230
Zhao W, Richardson JS, Mombourquette MJ et al (1995) An in vitro EPR study of the free radical scavenging actions of the lazaroid antioxidants U-74500 A and U-78517 F. Free Radic Biol Med 19:21–30
Johnson G, Lefer AM (1990) Protective effects of a novel 21-aminosteroid during splanchnic artery occlusion shock. Circ Shock 30:155–164
Inove M, Saito Y, Hirata E et al (1987) Regulation of redox states of plasma proteins by metabolism and transport of glutathione and related compounds. J Prot Chem 6:207–225
Meister A (1988) Glutathione metabohsm and its selective modification. J Biol Chem 263: 17205–17208
Robinson MK, Ahn MS, Rounds JD (1992) Parenteral glutathione monoester enhaucas tissue antioxidant stores. JPEN J Parenter Enteral Nutr 16:413–418
Griffith OW, Meister A (1985) Origin and turnover of mitochondrial glutathione. Proc Natl Acad Sci USA 82:4668–4672
Hagen TM, Yee AWT, Jones DP (1988) Glutathione uptake and protection against oxidative injury in isolated kidney cells. Kidney Int 34:74–81
Falsini S, Celiai MP, Angiolini P et al (1994) Glutatione ridotto e L-cisteina nello shock endotossinico nel ratto. Minerva Anestesiol 60:413–418
Novelli GP, Falsini S, Bracciotti G (1991) Exogenous glutathione increases endurance to muscle effort in mice. Pharmacol Res 23:149–155
Scardi S, Rossi R, Pieraccioli E et al (1993) Reduced glutathione prevents lipid peroxidation as expressed by ethane exhalation during aortic surgery in man. Minerva Anestesiol 59:S2–215
Mediati RD, Girardi G, Rossi R et al (1993) Glutathione administration prevents the increase of extravascular lung water during ischemia and reperfusion in man. Minerva Anestesiol 59: S2–214
Paternostro E, Scardi S, Pellegrini G (1993) Lung lipoperoxidative stress during hyperoxic anaesthesia: protective effects of reduced glutathione. Minerva Anestesiol 59:S2–213
Novelli GP, Casali R, Bonizzoli M et al (1993) Aumento della permeabilità capillare provocato dall’endotossina: protezione con antiossidanti e glutatione. Minerva Anestesiol 59: 211–216
Di Filippo A, Paternostro E, Scardi S et al (1992) Insufficienza multipla d’organo sperimentale nel ratto: effetti protettivi del glutatione ridotto. Acta Anaesth Ital 43:358–369
Novelli GP, Melani AM, Consales G et al (1994) Antioxidant drugs in cerebral and spinal ischemia. Minerva Anestesiol 60:543–546
Novelh GP (1990) I radicali liberi nello shock e in alcuni quadri ad esso correlati. In Albano et al (eds): Radicali liberi in patologia — nuovi orientamenti patogenetici e strategie chniche. Prag 6–9 December 1990
Aruoma OI, Halliwell B, Hoey BM (1989) The antioxidant properties of n-acetyl-cysteine. Free Radic Biol Med 6:593–597
Bernard GR (1991) N-acetylcysteine in experimental and clinical acute lung injury. Am J Med 91:S3 54–59
Spies CD, Reinahart K, Witt I et al (1994) Influence of n-acetylcysteine on indirect indicators of tissue oxygenation in septic shock patients: results from a prospective, randomized, double- blind study. Crit Care Med 22:1738–1746
Zimmerman JJ (1992) Radical viewpoints in critical illness. Crit Care Med 20:448–449
Yamauchi N, Watanabe N, Kuriyama H et al (1990) Suppressive effects of intracellular glutathione on hydroxyl radical production induced by tumor necrosis factor. Int J Cancer 46: 884–888
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© 1996 Springer-Verlag Italia, Milano
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Novelli, G.P., Casali, R., Falsini, S., Pieraccioli, E. (1996). Antioxidant Activity in the Therapy of Sepsis: From Experimental Data to Clinical Practice. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2203-4_17
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DOI: https://doi.org/10.1007/978-88-470-2203-4_17
Publisher Name: Springer, Milano
Print ISBN: 978-3-540-75014-7
Online ISBN: 978-88-470-2203-4
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