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The Endothelium: A New Secretory Organ Target or Promoter of Pathophysiological Derangements in ICU Patients

  • R. J. Gryglewski

Abstract

The vascular endothelium constitutes an interface between the blood and the rest of the tissues. It occupies a good strategic position for fulfilling its metabolic and endocrine functions. The former include removal and inactivation of biogenic amines, nucleotides, eicosanoids, lipoproteins, kinins or conversion of angiotensin I to angiotensin II, whereas the secretory activities comprise generation of prostacyclin (PGI2), nitric oxide (NO), endothelins (ET 1-3), plasminogen activators (t-PA), plasminogen activator inhibitor (PAI-1), thrombomodulin (TRM), platelet-derived growth factor ß (PDGF-ß), von-Willebrandt factor (v-WF), vascular cell adhesion molecule-1 (VCAM-1) and many others.

Keywords

Nitric Oxide Nitric Oxide Septic Shock iNOS mRNA Endotoxic Shock 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia, Milano 1996

Authors and Affiliations

  • R. J. Gryglewski

There are no affiliations available

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