The Endothelium: A New Secretory Organ Target or Promoter of Pathophysiological Derangements in ICU Patients

  • R. J. Gryglewski


The vascular endothelium constitutes an interface between the blood and the rest of the tissues. It occupies a good strategic position for fulfilling its metabolic and endocrine functions. The former include removal and inactivation of biogenic amines, nucleotides, eicosanoids, lipoproteins, kinins or conversion of angiotensin I to angiotensin II, whereas the secretory activities comprise generation of prostacyclin (PGI2), nitric oxide (NO), endothelins (ET 1-3), plasminogen activators (t-PA), plasminogen activator inhibitor (PAI-1), thrombomodulin (TRM), platelet-derived growth factor ß (PDGF-ß), von-Willebrandt factor (v-WF), vascular cell adhesion molecule-1 (VCAM-1) and many others.


Nitric Oxide Nitric Oxide Septic Shock iNOS mRNA Endotoxic Shock 
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© Springer-Verlag Italia, Milano 1996

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  • R. J. Gryglewski

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