Debate on DO2/\( \dot{V} \)O2 Dependency During Inotropic Treatment

  • G. Gutierrez


Few topics in critical care medicine are as controversial as the clinical significance of the systemic DO2-\( \dot{V} \)O2 relationship (1, 2). Even the definition of these variables has been a subject of debate, as some investigators maintain that the term O2 delivery should be reserved to denote the rate of oxygen reaching the cell mitochondria, whereas the term O2 transport is more indicative of the rate of oxygen carried by arterial blood to tissue capiharies (3). The phrase “oxygen offering” has been proposed to define the product of the cardiac output and the arterial O2 content, since it emphasizes the intrinsic degree of control that tissues have over their rate of O2 utilization (4). Similarly, the term O2 uptake has been used in lieu of O2 consumption, since an unspecified amount of oxygen extracted from capillary blood is used for nonoxidative cellular functions, including the synthesis of nitric oxide and the generation of O2 free radical species. For the purposes of this paper, the term O2 delivery (DO2) refers to the rate of O2 carried by arterial blood to the tissue capillaries and the term O2 consumption (\( \dot{V} \)O2) denotes the rate of oxygen uptake from arterial blood by the tissues.


Lactic Acidosis Oxygen Delivery Adult Respiratory Distress Syndrome Systemic Oxygen Transport Dopexamine Hydrochloride 
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© Springer-Verlag Italia, Milano 1996

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  • G. Gutierrez

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