Inadequate microcirculation in sepsis and shock causes tissue injury. In this chapter the small intestinal circulation will be used as an example of such tissue injury. The selection of the small intestine as an example is made for two reasons: this organ represents those that early suffer from inadequate microcirculation in critical illness and, moreover, the consequences of gut tissue injury are thought to be of significant importance for the further development into multiple organ dysfunction.


Xanthine Oxidase Fecal Peritonitis Mucosal Permeability Intestinal Blood Flow Increase Oxygen Extraction 
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  1. 1.
    Haglund U, Bulkley GB, Granger DN (1987) On the pathophysiology of intestinal ischemic injury. Acta Chir Scand 153:321–324PubMedGoogle Scholar
  2. 2.
    Kvietys PR, Granger DN (1982) Relation between intestinal blood flow and oxygen uptake. Am J Physiol 242:G202-G208PubMedGoogle Scholar
  3. 3.
    Bailey RW, Bulkey GB, Hamilton SR, Morris JB, Haglund U (1987) Protection of small intestine from nonocclusive mesenteric ischemic injury due to cardiogenic shock. Am J Surg 153:108–116PubMedCrossRefGoogle Scholar
  4. 4.
    Falk A, Redfors S, Myrvold H, Haglund U (1985) Small intestinal mucosal lesions in feline septic shock: a study on the pathogenesis. Circ Shock 17:327–337PubMedGoogle Scholar
  5. 5.
    Haglund U (1993) Therapeutic potential of intraluminal oxygenation. Crit Care Med 21: S69-S71PubMedCrossRefGoogle Scholar
  6. 6.
    Lundgren O, Haglund U (1978) The pathophysiology of the intestinal countercurrent exchanger. Life Sci 23:1411–1422PubMedCrossRefGoogle Scholar
  7. 7.
    Haglund U, Jodal M, Lundgren O (1984) The small bowel in arterial hypotension and shock. In: Sheperd AP, Granger DN (eds) Physiology of intestinal circulation. Raven, New York, pp 305–319Google Scholar
  8. 8.
    Dahn MS, Lange P, Lobdell K, Hans B, Jacobs LA, Mitchell RA (1987) Splanchnic and total body consumption differences in septic and injured patients. Surgery 101:69–80PubMedGoogle Scholar
  9. 9.
    Arvidsson D, Rasmussen I, Almqvist P, Niklasson F, Haglund U (1991) Splanchnic oxygen consumption in septic and hemorrhagic shock. Surgery 109:190–197PubMedGoogle Scholar
  10. 10.
    Wollert S, Rasmussen I, Lundberg C, Gerdin B, Arvidsson D, Haglund U (1993) Inhibition of CD 18-dependent adherence of polymorphonuclear leukocytes does not affect liver oxygen consumption in fecal peritonitis in pigs. Circ Shock 41:230–238PubMedGoogle Scholar
  11. 11.
    Rasmussen I, Haglund U (1992) Early gut ischemia in experimental fecal peritonitis. Circ Shock 38:22–28PubMedGoogle Scholar
  12. 12.
    Antonsson JB, Haglund UH (in press) Gut intramucosal pH and intraluminal p02 in a porcine model of peritonitis or hemorrhage. Gut (in press)Google Scholar
  13. 13.
    Ljungdahl M, Rasmussen I, Haglund U (1995) Flow dependency of gastro-intestinal mucosal acidosis in sepsis (Abstrac). Shock 3 [Suppl 2]:22CrossRefGoogle Scholar
  14. 14.
    Fink MP, Kaups KL, Wang H, Rothschild HR (1991) Maintenance of superior mesenteric arterial perfusion prevents increased intestinal mucosal permeability in endotoxic pigs. Surgery 110:154–161PubMedGoogle Scholar
  15. 15.
    Fink MP, Cohn SM, Lee PC, Rothschild HR, Deniz YF, Wang H, Fiddian-Green RG (1989) Effect of lipopolysaccharide on intestinal intramucosal hydrogen ion concentration in pigs: Evidence of gut ischemia in a normodynamic model of septic shock. Crit Care Med 17: 641–646PubMedCrossRefGoogle Scholar
  16. 16.
    Granger DN, Rutili G, McCord JM (1981) Superoxide radicals in feline intestinal ischemia. Gastroenterology 81:22–29PubMedGoogle Scholar
  17. 17.
    Parks DA, Bulkley GB, Granger DN, Hamilton SR, McCord JM (1982) Ischemic injury in the cat small intestine: role of superoxide radicals. Gastroenterology 82:9–15PubMedGoogle Scholar

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© Springer-Verlag Italia, Milano 1996

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  • U. Haglund

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