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Hyperbaric Oxygen Therapy in Ophthalmology

  • R. Magni
  • G. Oriani
  • G. C. Modugno

Abstract

Oxygen is obviously a determining element for the retina. It has two purposes: the first is the more classic one and is represented by aerobic glycolysis (in the inner layers of the retina), anaerobic glycolysis (outer layers of the retina), and by the other characteristic metabolic functions of the oxygen in maintaining the homeostasis of the retina tissues. Oxygen also has a determining role in the resynthesis of visual photopigment. In carrying out research into the chorioretinal oxygenation in humans, it can be assumed that for every important modification in oxygen availability at a chorioretinal level there is a modification in the visual function. Ischemic alterations in the retina, although transitory, cause a temporary or permanent reduction in vision. According to recent experimental evidence, an increase in oxygen availability would cause an improvement in vision [1, 2].

Keywords

Multiple Sclerosis Hyperbaric Oxygen Retinal Vein Occlusion Cystoid Macular Edema Branch Retinal Vein Occlusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Oriani G, Magni R, Michael M, Musini A, Durante A, Campagnoli P, Brancato R (1994) Assessment of visual contrast sensitivity in Hyberbaric oxygen. Undersea Hyperb Med 21: 387–390PubMedGoogle Scholar
  2. 2.
    Oriani G, Magni R, Durante A, Michael M, Giordano-Resti A, Brancato R (1994) Effects of HBO on visual function. II. Stereopsis. Proc loth Annual Meeting of the European Underwater and Baromedical Society on Diving and Hyperbaric Medicine. Istanbul, Turkey, 4–8 Sept, M. Gimsit (ed): 99–102Google Scholar
  3. 3.
    Oriani G, Magni R, Musini A, Meazza D, Brancato R (1990) A new electrophysiological test to assess ophthalmological benefits of hyperbaric oxygen treatment, J Hyperb Med 54: 231–237Google Scholar
  4. 4.
    Anderson B, Saltzman HA (1964) Retinal oxygen utilization by hyperbaric blackout. Arch Ophthalmol 72: 792–795PubMedCrossRefGoogle Scholar
  5. 5.
    Hertzog LM, Meyer GW, Carson S, Strauss MB, Hart GB (1992) Central retinal artery occlusion treated with hyperbaric oxygen. J Hyperb Med 7: 33–42Google Scholar
  6. 6.
    Cho S, Choi MS, Lee YJ, Choi SJ, Park YS, Shin HT (1990) Effect of hyperbaric oxygen therapy on central retinal artery occlusion associated with systemic lupus erythematosus (a case report). Proc Tenth International Congress on Hyperbaric Medicine. Amsterdam, The Netherlands. a-18 Aug 1990. Undersea Biomed Res 17 (Suppl): 38Google Scholar
  7. 7.
    Flower RW, Patz A (1971) The effect of hyperbaric oxygenation on retinal ischemia. Invest Ophthalmol 10: 605–616PubMedGoogle Scholar
  8. 8.
    Herbstein et al. (1980) Retinal vascular changes after the treatment with HBO. Med J Anesthesiol 140: 728Google Scholar
  9. 9.
    Meyer GW, Hart GB, Strauss MB (1990) Central retinal artery treated with hyperbaric oxygen. 18th Annual Undersea Hyperbaric Medical Society Pacific Chapter Meeting, 1–2 NovGoogle Scholar
  10. 10.
    Pelaia P, Volturo P, Rocco M, Vitullo F, Picardo V (1990) Hyperbaric oxygen therapy in the central (CRVO) and branch retinal vein occlusion (BRVO). Proc Tenth International Congress on Hyperbaric Medicine. Amsterdam, The Netherlands. 11–18 Aug 1990. Undersea Biomed Res 17 (Suppl): 110–114Google Scholar
  11. 11.
    Pelaia P, Picardo V, Volturo P, Vitullo V, Sposato M, Crescenzi F, Bozzoni F (1990) Central venous retinal thrombosis and hyperbaric oxygen treatment. Hyperbaric Medicine, Proceedings of the Joint Meeting: 2nd Swiss Symposium on Hyperbaric Medicine and 2nd European Conference on Hyperbaric Medicine, Basel 265–268Google Scholar
  12. 12.
    Pelaia P, Volturo P, Vitullo V, Picardo V. HBO in the treatment of central venous retinal thrombosis: 3 years of clinical experience. Hyperbaric Medicine, Proceedings of the Joint Meeting: 2nd Swiss Symposium on Hyperbaric Medicine and 2nd European Conference on Hyperbaric Medicine, BaselGoogle Scholar
  13. 13.
    Picardo V, Pelaia P, Mannino G, Bozzoni F, Ciatto D, Volturo P, Messina A, Ruggeri G, Rizzo G, Tamanti N, Giglio G, Crescenzi F (1989) La ossigenoterapia iperbarica nel trattamento della patologia venosa occlusiva retinica. Clin Ocul 10: 427–433Google Scholar
  14. 14.
    Reissman P, Beiran I, Nachum Z, Scharf J, Miller B, Melamed Y (1989) Hyperbaric oxygen and nifedipine treatment for recent onset central retinal artery occlusion. Proc XV Annual Meeting of the European Undersea Biomedical Society (EUBS), Eilat, Israel 17–21: 370–375Google Scholar
  15. 15.
    Roy M, Bartow W, Ambrus J, Fauci A, Collier B, Titus J (1989) Retinal leakage in retinal vein occlusion: reduction after hyperbaric oxygen. Ophthalmologica 198: 78–83PubMedCrossRefGoogle Scholar
  16. 16.
    Yn X Huang JG (1991) Hyperbaric oxygen treatment for cystoid macular edema secondary to retinal vein occlusion. Chung Hua Yen Ko Tsa Chih 27: 216–218Google Scholar
  17. 17.
    Bird AC (1984) Retinal edema. Introduction of the first international cystoid macular edema symposium. Sury Ophthalmol 28: 433CrossRefGoogle Scholar
  18. 18.
    Jampol LM (1982) Pharmacologic therapy of aphakic macular edema. A review. Ophthalmology 89: 891PubMedGoogle Scholar
  19. 19.
    Pfoff DS, Thom SR (1987) Preliminary report on the effect ofhyperbaric oxygen on cystoid macular edema. J Cataract Refract Surg 13: 136PubMedGoogle Scholar
  20. 20.
    Ogura Y, Takahashi M, Ueno S, Honda Y (1987) Hyperbaric oxygen treatment for chronic cystoid macular edema after branch retinal vein occlusion. Am J Ophthalmol; 104: 301–302PubMedGoogle Scholar
  21. 21.
    Mandai M, Ogura Y, Honda Y (1990) Effects of hyperbaric oxygen treatment on macular edema. Folia Ophthalmol Jpn 41: 578–583Google Scholar
  22. 22.
    Benner JD, Xiaoping M (1992) Locally administered hyperoxyc therapy for aphakic cystoid macular edema. Am J Ophthalmol 113: 104–105PubMedGoogle Scholar
  23. 23.
    Guy J, Schatz NJ (1986) Hyperbaric oxygen in the treatment of radiation-induced neuropathy. Ophthalmology 93: 1083–1088PubMedGoogle Scholar
  24. 24.
    Brown GC, Shields JA, Sanborn G et al. (1982). Radiation optic neuropathy. Ophthalmolog; 89 1489–1493Google Scholar
  25. 25.
    Roden D, Bosley TM, Fowble B, Clark J, Savino PJ, Sergott RC, Schatz NJ (1990) Delayed radiation injury to the retrobulbar optic nerves and chiasm. Ophthalmology 97: 346–351PubMedGoogle Scholar
  26. 26.
    Guy J, Schatz NJ (1990) Effectiveness of hyperbaric oxygen in treating radiation injury to the optic nerves and chiasm. Ophthalmology 97: 1246–1247PubMedGoogle Scholar
  27. 27.
    Viqueira Caamano J, de Lara A (1984) HBO treatment of 525 cases of diabetic retinopathy. HBO applications in other types of ocular pathology. In: Diving and hyperbaric medicine. Proc IX Congress of the EUBS. Desola J (ed) CRIS Barcelona: 169–178Google Scholar
  28. 28.
    Koenig F, Bandello F (1985) Les stades initiaux de la retinopathie diabetique. Statistique, fond d’oeil et angiographie. Rev Chibret Ophthalmol 105: 137Google Scholar
  29. 29.
    Boijc L, Kovacevic H, Gosovic S, Denoble P (1990) The effect of hyperbaric oxygen on glaucoma: a prospective study. Hyperbaric Medicine, Proceedings of the Joint Meeting: 2nd Swiss Symposium on Hyperbaric Medicine and 2nd European Conference on Hyperbaric Medicine, Basel 273–278Google Scholar
  30. 30.
    Boijc L, Racic G, Gosovic S, Kovacevic H (1993) The effect of hyperbaric oxygen breathing on the visual field in glaucoma. Acta Ophthalmologica; 71: 315–319CrossRefGoogle Scholar
  31. 31.
    Layton DD, Mackay RP (1958) Office management of multiple sclerosis. Med Clin North Am; 42: 103–110PubMedGoogle Scholar
  32. 32.
    Boschetty V, Cernoch J (1970) Aplikace Kysliku za pretlaku u nekterych neurologickych onemocneni. Bratisl Lek Listy 53: 298–302PubMedGoogle Scholar
  33. 33.
    Baixe JH (1978) Bilan de onze annees d’activité en medicine hyperbare. Med Aer Spatiale Med Subaquatique Hyperbare 17: 90–92Google Scholar
  34. 34.
    Neubauer RA (1978) Treatment of multiple sclerosis with monoplace hyperbaric oxygenation. J Fla Med Assoc 65: 101PubMedGoogle Scholar
  35. 35.
    Neubauer RA (1980) Exposure of multiple sclerosis patients to hyperbaric oxygen at 1,5–2 ATA: a preliminary report. J Fla Med Assoc 67:498–504PubMedGoogle Scholar
  36. 36.
    Formai C, Sereni G, Zannini D. L’ossigenoterapia iperbarica nel trattamento della sclerosi multipla. Procedings 14th Congresso Nazionale di Medicina Subacquea ed IperbaricaGoogle Scholar
  37. 37.
    Pallotta R, Anceschi S, Costagliola N et al. (1980) Prospettive di terapia iperbarica nella sclerosi a placche. Ann Med Navale 85: 57–62Google Scholar
  38. 38.
    Schumacher GA, Beebe G. Kibler RF et al. (1965) Problems of experimental trials of therapy in multiple sclerosis: report by the Panel of the Evaluation of Experimental Trials of Therapy in Multiple Sclerosis. Ann NY Acad Sci 122: 552–568CrossRefGoogle Scholar
  39. 39.
    Kurtzke JF (1965) Further notes on disability evaluation in multiple sclerosis with scale modifications. Neurology 15: 654–661PubMedCrossRefGoogle Scholar
  40. 40.
    Kurtzke JF (1981) A proposal for a uniform minimal record of disability in multiple sclerosis. Acta Neurol Scand (Suppl 87 ) 64: 110–129Google Scholar
  41. 41.
    Brown JR (1980) Problems in evaluating new treatments for multiple sclerosis. Neurology; 30 (7: Part 2): 8–11PubMedCrossRefGoogle Scholar
  42. 42.
    Feigin I, Budzilovich GN (1980) The influence of the ground substance on the extracellular water of normal and edematous human brain: focal edema and the demyelinating diseases, including multiple sclerosis. J Neuropathol Exp Neurol 39: 13–29PubMedCrossRefGoogle Scholar
  43. 43.
    Bauer HJ (1978) Problems of symptomatic therapy in multiple sclerosis. Neurology 28 (9: Part 2): 8–20PubMedCrossRefGoogle Scholar
  44. 44.
    Prineas JW, Connell F (1978) The fine structure of chronically active multiple sclerosis plaques. Neurology 28 (9: Part 2): 68–75PubMedCrossRefGoogle Scholar
  45. 45.
    Poser CM (1980) Exacerbations, activity, and progression in multiple sclerosis, Arch Neurol 37 471–474PubMedCrossRefGoogle Scholar
  46. 46.
    Lumsden CE (1972) The clinical pathology of multiple sclerosis. McAlpine D, Lumsden CE, Acheoson ED (eds) Multiple sclerosis: a reappraisal, 2nd edn. Churchill Livingstone, Edinburgh 317–319Google Scholar
  47. 47.
    Fisher BH, Marks M, Reich T (1983) Hyperbaric-oxygen treatment of multiple sclerosis. A randomized, placebo-controlled, double-blind study. N Engl J Med 308: 181–186CrossRefGoogle Scholar
  48. 48.
    Barbieri S, Pirovano C, Cislaghi G, Albonico G, Oriani G, Scarlato G, Mariani C. (1988) Longterm hyperbaric oxygen in multiple sclerosis: a placebo controlled, double blind trial with evoked potentials studies. Annals of Hyperbaric Medicine 1: 44–48Google Scholar
  49. 49.
    Henkind P (1964) Hyperbaric oxygen and corneal neovascularization. Lancet1964; 2: 836PubMedCrossRefGoogle Scholar
  50. 50.
    Lazar M, Lieberman TW, Irving HL (1968) Hyperbaric oxygenation and corneal neovascularization in the rabbit. Am J Ophthalmol 66: 107–110PubMedGoogle Scholar
  51. 51.
    Ashton N, Cook C (1954) Direct observation of the effect of oxygen on developing vessels: preliminary report. Br J Ophthalmol 38: 433PubMedCrossRefGoogle Scholar
  52. 52.
    Michaelson IC, Herz N, Kertesz D (1954) Effect of increased oxygen concentration on new vessel growth in the adult cornea. Br J Ophthalmol 38: 588PubMedCrossRefGoogle Scholar
  53. 53.
    Nichols CW,Yanoff M, Hall DA, Lambertsen CJ (1972) Histologic alterations produced in the eye by oxygen at high pressure. Arch Ophthalmol 87: 417–421PubMedCrossRefGoogle Scholar
  54. 54.
    Modugno G (1990) First results of keratoconus treatment with HBO. Proc of the Tenth International Congress on Hyperbaric Medicine. Amsterdam, The Netherlands. n-18 Aug 1990. Undersea Biomed Res 17 (Suppl): 115–117Google Scholar
  55. 55.
    Chace KV, Carubelli R, Nordquist RE, Rowsey JJ (1991) Effect of oxygen free radicals on corneal collagen. Free Radic Res Commun 12–13 pt 2: 591–594CrossRefGoogle Scholar
  56. 56.
    De La Paz M, Patrinely JR, Marines HM (1992) Appling D. Adjunctive hyperbaric oxygen in the treatment of bilateral cerebro-rhino-orbital mucormycosis. Am J Ophthalmol 114: 208–211Google Scholar
  57. 57.
    Ehler WJ, Bonney CH, Lam KW, Cissik H (1987) Hyperbaric induction of ocular hyperuricosis. J Hyperb Med 2: 69–73Google Scholar
  58. 58.
    Ehler WJ, Bonney CH, Lam KW, Butzin CA (1989) Pressure Pression induced ocular hyperuricosis. Undersea Biomed Res 16 (Suppl): 76Google Scholar
  59. 59.
    Palmquist BM, Barr PO, Fagerholm PP, Philipson BT (1978) Lens myopia and nuclear cataract induced by hyperbaric oxygen therapy. Transactions of the Swedish Ophthalmological Society 1977. Acta Ophthalmologica 56: 476Google Scholar
  60. 60.
    Palmquist BM, Philipson B, Barr PO (1984) Nuclear cataract and myopia during hyperbaric oxygen therapy. Br J Ophthalmol 68: 113–117PubMedCrossRefGoogle Scholar
  61. 61.
    Shocket SS, Esterson J, Bradford B, Michaelis M, Richards RD (1972) Induction of cataracts in mice by exposure to oxygen. Isr J Med Sci 8: 1596–1601Google Scholar
  62. 62.
    Fisher BH, Marks M, Reich T (1983) Hyperbaric-oxygen treatment of multiple sclerosis. A randomized, placebo-controlled, double-blind study. N Engl J Medicine 308: 181–186CrossRefGoogle Scholar
  63. 63.
    Lyne AJ (1978) Ocular effects of hyperbaric oxygen. Trans Ophthalmol Soc UK 98: 66–68PubMedGoogle Scholar
  64. 64.
    Anderson B, Farmer JC (1978) Hyperoxic myopia. Trans Am Ophthalmol Soc 76: 116–124PubMedGoogle Scholar
  65. 65.
    Lambrou GN, Kopferschmitt J, Jaeger A, Brini A (1987) Slow-recovering central scotoma: a side effect of hyperbaric oxygen used on multiple sclerosis patients. J FR Ophthalmol 10: 51–59Google Scholar
  66. 66.
    Kopferschmitt J, Sauder Ph, Jaeger A, Mantz JM (1990) Iatrogenic ophthalmological effects of HBO: a case involving multiple sclerosis. Hyperbaric Medicine, Proceedings of the Joint Meeting: 2nd Swiss Symposium on Hyperbaric Medicine and 2nd European Conference on Hyperbaric Medicine, Basel 269–272Google Scholar
  67. 67.
    Nichols CW, Lambertsen CJ, Clark JM (1969) Transient unilateral loss of vision associated with oxygen at high pressure. Arch Ophthalmol 81: 548PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia, Milano 1996

Authors and Affiliations

  • R. Magni
    • 1
  • G. Oriani
    • 2
  • G. C. Modugno
    • 3
  1. 1.Department of Ophthalmology and Vision SciencesScientific Institute San Raffaele Hospital, Milan UniversityMilanItaly
  2. 2.Anaesthesia, Intensive and Hyperbaric Care DepartmentGaleazzi Orthopaedic InstituteMilanItaly
  3. 3.Undersea Hyperbaric Postgraduate Medical SchoolD’Annunzio UniversityChietiItaly

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