Oxygen and Healing Wounds: Tissue-Bone Repair Enhancement

  • J. Niinikoski
  • T. K. Hunt


The major uses of hyperbaric oxygenation are based on its application as a therapeutic adjunct in the management of repair in tissues that are chronically hypoxic, where local oxygen tension is below optimal for healing. The injury that originally creates the wound injures local blood vessels. Injured vessels thrombose while nearby vessels dilate; thrombocytes and leukocytes adhere to the endothelium, and the leukocytes soon migrate through the vessels walls into the wounded tissue. Within a few hours the injured area becomes infiltrated with rapidly metabolizing leukocytes and macrophages that will later be r eplaced by fibroblasts, which require oxygen at high partial pressures in order to perform their functions. Consequently, the oxygen requirement of the repair process is greatest at the very time when the local circulation is least able to satisfy it. Because the requirements of inflammation and repair overwhelm the capacity of nutritional supply, the wound soon faces a local energy crisis [19].


Oxygen Tension Chronic Granulomatous Disease Hyperbaric Oxygen Pyoderma Gangrenosum Wound Edge 
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Copyright information

© Springer-Verlag Italia, Milano 1996

Authors and Affiliations

  • J. Niinikoski
    • 1
  • T. K. Hunt
    • 2
  1. 1.Department of SurgeryUniversity of TurkuTurkuFinland
  2. 2.Department of SurgeryUniversity of California School of MedicineSan FranciscoUSA

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