fMRI Using True 3D Sequences and Full Positional Registration
Numerous studies of brain activation using magnetic resonance imaging (MRI) [1–5] have demonstrated spatially localised signal changes that correlate with the temporal format of the study protocol being used. In most cases the studies consist of repeated acquisition of single or multiple two-dimensional slices of a chosen region of the brain. The time course of signals from each individual voxel is then analysed to extract components that correlate with the time course of the applied stimulus [6, 7]. This procedure has high sensitivity, but is vulnerable to the presence of correlated signal changes that arise from sources other than brain activation. In a previous paper  we showed that head motion which correlated with the motor or visual stimuli being applied was present in all subjects that were investigated. These displacements changed the anatomical content of image voxels and resulted in signal changes that simulated activation of the brain.
KeywordsFunctional Magnetic Resonance Imaging Image Interpolation Image Voxels Sinc Interpolation Localise Signal Change
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