Cerebral Perfusion Imaging with Gadolinium Chelates and Iron Oxides in Humans
Susceptibility-induced signal loss following the bolus injection of paramagnetic contrast agents coupled with dynamic magnetic resonance imaging (MRI) has enabled the generation of cerebral blood volume (CBV) maps which reflect cerebral perfusion [1-4]. Both gadolinium-and dysprosium-based paramagnetic contrast agents and endogenous substances have been used for CBV and functional MRI (fMRI) studies [1-6]. More recently, superparamagnetic iron oxides (SPIO) with a stronger susceptibility effect than paramagnetic chelates have been applied in humans as well [7, 8]. We describe clinical results with the current approved dose of gadolinium chelates (0.1 mmol/kg body weight), present results with a neutral gadolinium chelate at higher doses (0.1-0.5 mmol/kg bodyweight), and take a look into the future with the first clinical results of a novel bolus-injectable SPIO contrast agent (Resovist, SH U 555A, Schering AG, Berlin) to induce susceptibility contrast in the brain .
KeywordsCerebral Blood Volume Functional Magnetic Resonance Imaging Superparamagnetic Iron Oxide Gadopentetate Dimeglumine Gadolinium Chelate
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- 2.Fisel CR, Ackerman JL, Buxton RB, et al (1991) MR contrast due to microscopically heterogeous magnetic susceptibility: Numerical simulations and applications to cerebral physiology. Magn Reson Med 17: 336–347Google Scholar
- 3.Villringer A, Rosen BR, Belliveau JW, et al (1988) Dynamic imaging with lanthanide chelates in normal brain: Contrast due to magnetic susceptibility effects. Magn Reson Med 6: 164–174Google Scholar
- 4.Rosen BR, Belliveau JW, Aronen HJ, et al (1991) Susceptibility contrast imaging of cerebral blood volume: Human experience. Magn Reson Med 22: 293–299Google Scholar
- 5.Aronen HJ, Gazit IE, Louis DN, et al (1994) Cerebral blood volume maps of gliomas: Comparison with tumor grade and histologic findings. Radiology 191: 41–51Google Scholar
- 7.Bulte JWM, De Jonge MWA, Kamman RL, et al (1992) Dextran-magnetite particles: Contrast-enhanced MRI of blood-brain barrier disruption in a rat model. Magn Reson Med 23: 215–223Google Scholar
- 9.Reimer P, Schuierer G, Balzer T, Peters PE (1995) Application of a superparamagnetic iron oxide (Resovist) for MR imaging of human cerebral blood volume. Magn Reson Med (in press)Google Scholar
- 13.Schuierer G, Tigges A, Reimer P, Daldrup H, Peters PE (1995) The repeatability of MR-perfusion studies: a clinical study. Twelth Annual Meeting and Exhibition of the Society of Magnetic Resonance and European Society for Magnetic Resonance in Medicine and Biology, Nice, p. 84Google Scholar
- 16.Majumdar S, Zoghbi S, Gore JC (1988) Regional differences in rat brain displayed by fast MRI with superparamagnetic contrast agents. Magn Reson Med 6: 611–615Google Scholar