In 1907, George Whipple described the case of an adult man who died from an unknown disease characterized by the presence of a massive infiltration of small intestinal mucosa by voluminous and foamy PAS+ macrophages, mesenterial adenopathy, pleuritis, pericarditis and endocarditis. Thus, the multisystemic nature of the disease was evident, right from the original description. Only very recently has it been recognized that the disorder is due to an infection with Tropheryma whippelii, a gram-positive actinomycetes, perhaps precipitated by a preexisting defect of cellular immunity. Such an infection may virtually involve all organs and tissues, thus making an impressive polymorphism in the clinical features possible.
KeywordsLamina Propria Original Magnification Small Intestinal Mucosa Massive Infiltration Histological Demonstration
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