News on muscle relaxants

  • C. Melloni
  • F. Antolini
  • F. Sfogliaferri
Conference paper


The big news in the field of neuromuscular blocking agents is ... that there are no new drugs on the horizon. The shortage of money in the field of neuromuscular research derives from the simple fact that the pharmaceutical companies have no money to invest in market niches and perhaps from the perceived evidence that the drugs we have today are already highly sophisticated and there is no absolute need to improve them. Organon tried to launch a new fast-onset/fast-offset drug (rapacuronium), but it had dangerous side effects on the airways, especially a worrying incidence of bronchospasm and oxygen desaturations [1], and was therefore withdrawn from the formularies after a promising start. We are still short of a drug with clinical time actions similar to those of succinylcholine, and this is still a goal of pharmaceutical research in the field of the neuromuscular blocking agents, pushed by the continuous growth of day surgery/day anaesthesia.


Neuromuscular Blockade Neuromuscular Block Neuromuscular Blocking Agent Reversal Agent Adductor Pollicis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia, Milano 2004

Authors and Affiliations

  • C. Melloni
  • F. Antolini
  • F. Sfogliaferri

There are no affiliations available

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