Acute normovolaemic haemodilution
The potential risk of transmission of infectious diseases and of other adverse effects, including transfusion reaction, immunosuppression, transfusion-related acute lung injury, has reinforced a general reappraisal of transfusion and a critical analysis of its benefits, risks and costs in the clinical and surgical settings. At the same time, research into alternatives to allogeneic red blood cell transfusion and physiological effects of lower haemoglobin levels has been developed. Critically ill patients in intensive care units usually require red cell transfusion to compensate anaemia caused by bleeding or the need to augment oxygen delivery. Unfortunately, these critically ill patients may be more susceptible than others to the immunosuppressive complications of transfusion.
KeywordsHydroxyethyl Starch Major Liver Resection Improve Blood Flow Cell Salvage Preoperative Autologous Blood Donation
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- 3.Fahmy NR, Chandler HP, Patel DJ et al (1980) Hemodynamics and oxygen availability during acute hemodilution in conscious man (abstract). Anesthesiology 53 (Suppl): 584Google Scholar
- 4.Gallagher JD (1995) Hemodilution: physiology and limits of anemia. In: Lake CL, Moore RA (eds) Blood hemostasis, transfusion and alternatives in the perioperative period. Raven Press, New York, pp 345–380Google Scholar
- 15.American college of physicians (1992) Practice strategies for elective red blood cell transfusion. Ann Intern Med 116: 403–406Google Scholar
- 20.Petrovitch CT, Drumond JC (2001) Hemotherapy and hemostasis. In: Barash PJ, Cullen BF, Stoelting RK (eds) Clinical anesthesia, 4th edn Lippincott/Williams and Wilkins, Philadelphia, pp 201–236Google Scholar
- 23.Morgan GE, Mikhail MS, Murray MJ (2001) Clinical anesthesiology, 3th edn McGraw-Hill/Appleton & Lange, Philadelphia 433–471Google Scholar
- 25.Fraga AO (2002) Acute Normovolemic Hemodilution with Ringer’s lactate or hydroxyethyl starch 6% in dogs: cardiovascular, metabolic, respiratory and histopathological evaluation. Thesis, University of Sao Paulo Medical SchoolGoogle Scholar