Platelet transfusion: when, how and how much?

  • V. De Angelis


The use of platelets in therapy has become widespread in recent decades. The treatment of haematological and nonhaematological malignancies, bone marrow transplantation procedures and cardiac surgery are responsible for the vast majority of platelet transfusions. However, transfusion of platelets is associated with different post-transfusion reactions: infections due to bacterial contamination are the most frequent side effects of platelet transfusion, but, although less frequent, alloimmunisation, febrile nonhaemolytic reactions, viral infections and transfusion-associated lung injury (TRALI) are also detected by the network of haemovigilance [1]. Finally, platelet concentrates are very costly blood components, and blood and blood components are becoming increasingly scarce in Europe.


Platelet Count Thrombotic Thrombocytopenic Purpura Platelet Transfusion Platelet Concentrate Platelet Recovery 
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© Springer-Verlag Italia, Milano 2004

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  • V. De Angelis

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