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Ketamine, a general anaesthetic agent and more. A review on its use in and out the clinical setting

  • C. Ori
  • M. Dalsasso
  • U. Freo
Conference paper

Abstract

Ketamine is a non-competitive NMDA receptors antagonist with potent general anaesthetic and analgesic effects. NMDA receptors are involved in nociceptive modulation, in the wind-up phenomenon, in peripheral receptive fields expansion, in primary and secondary hyperalgesia, and in neuronal plasticity, a process implicated in central sensitisation of pain [1]. Ketamine also acts on nicotinic and muscarinic receptors, blocks sodium channels and interacts with µ, δ and κ opioid receptors.

Keywords

Cancer Pain Postherpetic Neuralgia Status Asthmaticus Club Drug Intravenous Ketamine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Italia, Milano 2004

Authors and Affiliations

  • C. Ori
  • M. Dalsasso
  • U. Freo

There are no affiliations available

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