LH-RH Antagonists: State of the Art and Future Perspectives

  • G. F. Weinbauer
  • E. Nieschlag
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 124)


Luteinizing hormone-releasing hormone (LH-RH) is produced in hypothalamic nuclei, travels via the portal blood to the anterior pituitary, and acts on gonadotropic cells by inducing the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The gonadotropic hormones, in turn, regulate gonadal steroid production and gametogenesis. Reproductive functions, therefore, are critically dependent on LH-RH whose stimulatory effects are determined by its pulsatile release pattern (Knobil 1980) and by the availability of high-affinity binding sites at the pituitary site (Clayton and Catt 1981). Consequently, interference with the binding of native LH-RH to its pituitary receptors will provoke alterations of gonadal functions.


GnRH Agonist GnRH Antagonist Hormone Antagonist Androgen Substitution 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • G. F. Weinbauer
    • 1
  • E. Nieschlag
    • 1
  1. 1.Institut für Reproduktionsmedizin der UniversitätWHO Kollaborationszentrum zur Erforschung der männlichen FertilitätMünsterGermany

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