LH-RH Agonists in the Treatment of Pancreatic Cancer
The incidence of adenocarcinoma of the exocrine pancreas is steadily increasing. Approximately 25000 new cases of pancreatic cancer are diagnosed yearly in the United States where this tumor now ranks as the fourth leading cause of death from malignancies (Connolly et al. 1987; Greenberger et al. 1987). The vast majority of pancreatic cancers are ductal adenocarcinomas, but other pancreatic carcinomas also occur. Histogenetically, more than 90% of these tumors are derived from the pancreatic ducts and thus about 60% are located in the head of the gland (Moossa et al. 1986). Ductal adenocarcinoma has a very poor prognosis, in part because most patients have advanced disease by the time of diagnosis. Early diagnosis and screening for nonendocrine pancreatic cancer is difficult, although the technology for detecting these small tumors is available (Blind and Dahlgren 1987; Douglass 1987; Anonymous 1986; Malt 1983).
KeywordsPancreatic Cancer Pancreatic Carcinoma Advanced Pancreatic Cancer Exocrine Pancreas Human Pancreatic Cancer Cell Line
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