Bone Mineral Content by Single- and Dual-Photon Absorptiometry in Thalassemic Patients

  • M.-H. Goni
  • V. Markussis
  • G. Tolis


β-Thalassemia major (β-TM) is a hereditary, fatal hemolytic anemia relatively common in Mediterranean countries. Chronic hypoxia secondary to anemia, extramedullary hematopoiesis, hepatosplenomegaly, osteoporosis, cardiac failure, and increased susceptibility to infections contribute to the mortality and morbidity associated with the disease. Hypertransfusion therapy, although it has dramatically increased the duration and quality of life of thalassemic patients, invariably leads to chronic iron overload, despite chelation, resulting in cardiomyopathy, hepatic cirrhosis, hyperpigmentation and multiple endocrine abnormalities, the most common being hypogonadotrophic hypogonadism.


Bone Mineral Density Bone Mineral Content Tanner Stage Gonadal Steroid Thalassemic Patient 


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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • M.-H. Goni
  • V. Markussis
  • G. Tolis

There are no affiliations available

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