Skip to main content

Pubertal Development in Female Thalassemics

  • Chapter
  • 83 Accesses

Abstract

Although the prognosis of transfusion-dependent thalassemia has improved greatly with more intensive transfusion regimens and chelation therapy, delayed puberty and hypogonadism are still common problems. The purpose of this study was to evaluate and to compare two groups one of which received regular iron chelation therapy and the other irregular iron chelation therapy or none.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Anastasi S, Caruso V, Magnano C, Leocata A (1991) The endocrine complications in thalassemia major. Pediatr Med Chir 13 (1): p 63–65

    PubMed  CAS  Google Scholar 

  2. Ando S, Giaccetto C, Bria M, Tagarelli A, Piro A, Seidita F, Brancati C (1987) Endocrine correlates of adrenal and testicular function with circulating ferritin plasma levels in adult thalassemic patients. Birth Defects 23 (5A): 459–468

    PubMed  CAS  Google Scholar 

  3. Danesi L, Scacchi M, De Martin M, Dubini A, Massaro P (1992) Evaluation of hypothalamicpituitary function in patients with thalassemia major. Endocrinol Invest 15 (3): 177–186

    CAS  Google Scholar 

  4. De Sanctis V, Vullo C, Katz M, Wonke B, Tanas R, Bagni B (1988) Gonadal function in patients with beta thalassemia major. Clin Pathol 41 (2): 133–137

    Article  Google Scholar 

  5. De Sanctis V, Vullo C, Katz M, Wonke B, Hoffbrand VA, Di Palma A (1989) Endocrine complications in thalassemia major. Prog Clin Biol Res 309: 77–83

    PubMed  Google Scholar 

  6. Janssen G, Schuster A, Ranke MB, Gobel U (1991) Combined hypophyseal function test in children with homozygous beta-thalassemia. Klin Padiatr 203: 104–108

    Article  PubMed  CAS  Google Scholar 

  7. De Montalembert M, Llados A, Hannedouche T. Girot R (1989) Treatment of posttransfusion iron overload by deferoxamine. Arch Fr Pediatr 46 (2): 99–105

    PubMed  Google Scholar 

  8. Mordel N, Birkenfeld A, Goldfarb AN, Rachmilewitz EA (1989) Successful full-term pregnancy in homozygous beta-thalassemia major: case report and review of the literature. Obstet Gynecol 73 (52): 837–840

    PubMed  CAS  Google Scholar 

  9. Shehadeh N, Hazani A, Rudolf MC, Peleg I, Benderly A, Hochberg Z (1990) Neurosecretory dysfunction of growth hormone secretion in thalassemia major. Acta paediatr Scand 79 (8-9): 790–795

    Article  PubMed  CAS  Google Scholar 

  10. Vullo C, De Sanctis V, Karz M, Wonke B, Hoffbrand AV (1990) Endocrine abnormalities in thalassemia. Ann NY Acad Sci 612: 293–310

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Gökçen, Ö., Malyali, D., Kanadikirik, E., Azizlerli, H. (1995). Pubertal Development in Female Thalassemics. In: Andò, S., Brancati, C. (eds) Endocrine Disorders in Thalassemia. Springer, Milano. https://doi.org/10.1007/978-88-470-2183-9_25

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-2183-9_25

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2185-3

  • Online ISBN: 978-88-470-2183-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics