Pituitary-Thyroid Function in Children with β-Thalassemia major

  • H. E. Tutar
  • G. Öcal
  • N. Akar
  • A. Arcasoy


Long-term survival of patients with thalassemia major has been improved by regular transfusion and chelation therapy [1]. However, multiple endocrine disturbances, including thyroid dysfunction, attributed to the chronic transfusional iron overload and causing morbidity and mortality in thalassemic patients are still a major problem [2, 3]. The purpose of the present study was to determine the incidence of pituitary-thyroid dysfunction and its relationship to various clinical and laboratory measurements in thalassemic patients.


Serum Ferritin Level Chelation Therapy Thalassemic Patient Thalassemia Major Pretransfusional Hemoglobin Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Zurlo MG, De Stefano P, Borgna-Pignatti C, Di Palma A, Piga A, Melevendi C, Di Gregorio F, Burattini MG, Terzoli S (1989) Survival and causes of death in thalassaemia major. Lancet 1: 27–29CrossRefGoogle Scholar
  2. 2.
    Costin G, Kogut MD, Hyman C, Ortega JA (1979) Endocrine abnormalities in thalassemia major. Am J Dis Child 133: 497–502PubMedGoogle Scholar
  3. 3.
    De Sanctis V, Vullo C, Katz M, Wonke B, Hoffbrand VA, Di Palma A, Bagni B (1989) Endocrine complications in thalassemia major. Prog Clin Biol Res 309: 77–83PubMedGoogle Scholar
  4. 4.
    De Luca F, Melluso R, Sobbrio G, Canfora G, Trimarchi F (1980) Thyroid function in thalassemia major. Arch Dis Child 55: 389–392PubMedCrossRefGoogle Scholar
  5. 5.
    Masala A, Meloni T, Gallisai D, Alagna S, Rovasio PP, Rassu S, Milia AF (1984) Endocrine functioning in multitransfused prepubertal patients with homozygous β-thalassemia. J Clin Endocrinol Metab 58: 667–670PubMedCrossRefGoogle Scholar
  6. 6.
    De Sanctis V, D’Ascola G, Tanas R, Vullo C, Bagni B (1985) Preclinical hypothyroidism in patients with β-thalassemia major. In: Sirchia G, Zanella A (eds) Thalassemia today: the Mediterranean experience. CTOMPM, Milan, pp 271–274Google Scholar
  7. 7.
    Magro S, Puzzonia P, Consarino C, Galati MC, Morgione S, Porcelli D, Grimaldi S, Tancre D, Arcuri V, De Sanctis V, Alberti A (1990) Hypothyroidism in patients with thalassemia syndromes. Acta Haematol (Basel) 84: 72–76PubMedCrossRefGoogle Scholar
  8. 8.
    Sabato AR, De Sanctis V, Atti G, Capra L, Bagni B, Vullo C (1983) Primary hypothyroidism and the low T3 syndrome in thalassaemia major. Arch Dis Child 58: 120–127PubMedCrossRefGoogle Scholar
  9. 9.
    Livadas DP, Sofroniadou K, Souvatzoglou A, Boukis M, Siafaka L, Koutras DA (1984) Pituitary and thyroid insufficiency in thalassaemic haemosiderosis. Clin Endocrinol 20: 435–443CrossRefGoogle Scholar
  10. 10.
    Cavallo L, Licci D, Acquafredda A, Marranzini M, Beccasio R, Scardino ML, Altomare M, Mastro F, Sisto L, Schettini F (1984) Endocrine involvement in children with β-thalassemia major. Transverse and longitudinal studies. I. Pituitary-thyroidal axis function and its correlation with serum ferritin levels. Acta Endocrinol (Copenh) 107: 49–53PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • H. E. Tutar
  • G. Öcal
  • N. Akar
  • A. Arcasoy

There are no affiliations available

Personalised recommendations