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Plasma Growth Hormone-Binding Protein and Liver Receptor in Thalassemic Patients

  • M. C. Postel-Vinay
  • M. Fontoura
  • M. De Montalembert
  • F. Pérignon
  • R. Brauner
  • R. Rappaport
  • R. Girot

Abstract

Children with thalassemia major often present with growth failure, the mechanism of which is not clear. They are not GH deficient but their plasma insulin-like growth factor I (IGFI) activity is markedly reduced [1–5]. Therefore, the cause of the growth defect is likely to be at the GH receptor or post-receptor level: in either case it would lead to impairment of GH-induced generation of IGFI.

Keywords

Chelation Therapy Growth Failure Thalassemic Patient Thalassemia Major Thalassemic Child 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • M. C. Postel-Vinay
  • M. Fontoura
  • M. De Montalembert
  • F. Pérignon
  • R. Brauner
  • R. Rappaport
  • R. Girot

There are no affiliations available

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