Abstract
Children with thalassemia major often present with growth failure, the mechanism of which is not clear. They are not GH deficient but their plasma insulin-like growth factor I (IGFI) activity is markedly reduced [1–5]. Therefore, the cause of the growth defect is likely to be at the GH receptor or post-receptor level: in either case it would lead to impairment of GH-induced generation of IGFI.
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© 1995 Springer-Verlag Berlin Heidelberg
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Postel-Vinay, M.C. et al. (1995). Plasma Growth Hormone-Binding Protein and Liver Receptor in Thalassemic Patients. In: Andò, S., Brancati, C. (eds) Endocrine Disorders in Thalassemia. Springer, Milano. https://doi.org/10.1007/978-88-470-2183-9_2
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DOI: https://doi.org/10.1007/978-88-470-2183-9_2
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-2185-3
Online ISBN: 978-88-470-2183-9
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