Plasma Growth Hormone-Binding Protein and Liver Receptor in Thalassemic Patients
Children with thalassemia major often present with growth failure, the mechanism of which is not clear. They are not GH deficient but their plasma insulin-like growth factor I (IGFI) activity is markedly reduced [1–5]. Therefore, the cause of the growth defect is likely to be at the GH receptor or post-receptor level: in either case it would lead to impairment of GH-induced generation of IGFI.
KeywordsChelation Therapy Growth Failure Thalassemic Patient Thalassemia Major Thalassemic Child
Unable to display preview. Download preview PDF.