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Growth in Homozygous β-Thalassemic Patients

  • M. C. Galati
  • G. Raiola
  • P. Puzzonia
  • C. Consarino
  • S. Grimaldi
  • S. Morgione
  • E. Santilli
  • R. Mancuso
  • A. Vero
  • S. Magro

Abstract

Advances in transfusion and chelation therapy have significantly increased the life expetancy of patients with homozygous β-thalassemia. However, a variety of endocrine abnormalities frequently occur in such patients. A number of studies have shown that as thalassemic patients approach the age of puberty, a percentage develop growth retardation [1]. The growth failure of these patients has been attributed to hypothyroidism, delayed sexual maturation, hypogonadism, zinc deficit, and desferrioxamine toxicity. The aim of the present investigation was to evaluate a possible role of the GHRH-GH-IGF-I axis dysfunction in growth failure in homozygouys β-thalassemia.

Keywords

Thalassemic Patient Height Standard Deviation Score Growth Plate Chondrocytes Plasma IGFI Level Auxological Data 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • M. C. Galati
  • G. Raiola
  • P. Puzzonia
  • C. Consarino
  • S. Grimaldi
  • S. Morgione
  • E. Santilli
  • R. Mancuso
  • A. Vero
  • S. Magro

There are no affiliations available

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