Growth in Homozygous β-Thalassemic Patients
Advances in transfusion and chelation therapy have significantly increased the life expetancy of patients with homozygous β-thalassemia. However, a variety of endocrine abnormalities frequently occur in such patients. A number of studies have shown that as thalassemic patients approach the age of puberty, a percentage develop growth retardation . The growth failure of these patients has been attributed to hypothyroidism, delayed sexual maturation, hypogonadism, zinc deficit, and desferrioxamine toxicity. The aim of the present investigation was to evaluate a possible role of the GHRH-GH-IGF-I axis dysfunction in growth failure in homozygouys β-thalassemia.
KeywordsThalassemic Patient Height Standard Deviation Score Growth Plate Chondrocytes Plasma IGFI Level Auxological Data
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