Thalassemia and Endocrinopathies: Multicenter Study of 3092 Patients

  • Italian Working Group on Endocrine Complications in Non-Endocrine Diseases


Data regarding the prevalence of endocrine dysfunction in patients with β-thalassaemia major are limited [1, 2], We report the results of a collaborative study of endocrine complications in a large series of patients with β-thalassemia major followed in pediatric and hematology departments throughout Italy.


Iron Overload Thalassaemia Major Endocrine Abnormality Primary Hypothyroidism Thalassemia Major Patient 
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  1. 1.
    Brezis M. Shalev O, Leibel B, Bernheim J, Ben-Ishay D (1980) Phosphorus retention and hypoparathyroidism associated with transfusional iron overload in thalassaemia. Miner Electrolyte Metab 4: 57–61Google Scholar
  2. 2.
    Costin G, Kogut M, Hyman CB, Ortega J (1979) Endocrine abnormalities in thalassaemia major. Am J Dis Child 133: 497–502PubMedGoogle Scholar
  3. 3.
    De Sanctis V, Vullo C, Katz M et al. (1989) Endocrine complications in thalassaemia major. In: Buckner CD, Gale RP, Lucarelli G (eds) Advances and controversies in thalassaemia therapy. Liss, New York; pp 77–83Google Scholar
  4. 4.
    Lassmann MN, Genel M, Wise JK, Hendler R, Felig P (1974) Carbohydrate homeostasis and pancreatic islet cell function in thalassaemia. Ann intern Med 80: 65–69Google Scholar
  5. 5.
    Rahier J, Loozen S, Goebbels RM, Abrrahem M (1987) The haematochromatic human pancreas: a quantitative immunohistochemical and ultrastructural study. Diabetologia 30: 5–12PubMedCrossRefGoogle Scholar
  6. 6.
    Saudek CD, Hemm RM, Peterson CM (1977) Abnormal glucose tolerance in p–thalassemia major. Metabolism 26: 43–52PubMedCrossRefGoogle Scholar
  7. 7.
    Suda K (1985) Hemosiderin deposition in the pancreas. Arch Pathol Lab Med 109: 996–999PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1995

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  • Italian Working Group on Endocrine Complications in Non-Endocrine Diseases

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