Natriuretic Peptides in Antarctic Teleosts: Cardiac Receptors in Chionodraco hamatus and Trematomus bernacchii

  • Maria C. Cerra
  • Rosa Mazza
  • Daniela Pellegrino
  • Bruno Tota


The myocardium of teleosts, like the atrial myocardium of homeotherm vertebrates, is a major site of synthesis and release of various structuraly related hormones commonly referred to as natriuretic peptides (NPs). This family of vasorelaxant, diuretic, and natriuretic substances is involved in both cardiovascular and body fluid homeostasis of fish [1, 2, 3, 4].


Natriuretic Peptide Brain Natriuretic Peptide Atrial Natriuretic Peptide Atrial Natriuretic Factor Cardiac Region 
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  1. 1.
    Evans DH (1990) An emerging role for a cardiac peptide hormone in fish osmoregulation. Ann. Rev. Physiol. 52: 43–60CrossRefGoogle Scholar
  2. 2.
    Olson KR (1992) Blood and extracellular fluid volume regulation: role of the renin-angiotensin system, kallykrein-kinin system, and atrial natriuretic peptides. In: Fish physiology, Hoar WS, Randall DJ eds Academic Press Inc Orlando, Florida, Vol XIIB pp 135–254Google Scholar
  3. 3.
    Takei Y, Balment RJ (1993) Biochemistry and physiology of a family of eel natriuretic peptides. Fish Physiol Biochem 11:183–188CrossRefGoogle Scholar
  4. 4.
    Acierno R, Axelsson A, Tota B, Agnisola C, Nilsson S (1991) Hypotensive effect of atrial natriuretic factor (ANF) in the Atlantic cod, Gadus morhua. Comp. Biochem Physiol 99C: 11–14Google Scholar
  5. 5.
    Olson KR, Duff DW (1992) Cardiovascular and renal effects of eel and rat atrial natriuretic peptide in rainbow trout, Salmo gairdneri. J Comp Physiol B, 162:408–415PubMedCrossRefGoogle Scholar
  6. 6.
    Oudit GY, Butler DG (1995) Cardiovascular effects of arginine vasotocin, atrial natriuretic peptide, and epinephrine in freshwater eels. Am J Physiol 268: R1273–R1280PubMedGoogle Scholar
  7. 7.
    Sverdrup A, Helle KB (1994) Different patterns of relaxation by atrial natriuretic peptide in major blood vessels of two distantly related teleosts. Reg Peptides, 53:89–101CrossRefGoogle Scholar
  8. 8.
    O’Grady SM, DeVries AL (1982) Osmotic and ionic regulation in polar fishes. J Exp Mar Biol Ecol 57: 219–228CrossRefGoogle Scholar
  9. 9.
    Dobbs G, DeVries AL, (1975) Renal function in Antarctic teleost fishes: serum and urine composition. Mar Biol 29:59–70CrossRefGoogle Scholar
  10. 10.
    Gonzales-Cabrera P, Dowd F, Pedibhotla VK, Rosario R, Stanley-Samuelson D, Petzel D (1995) Enhanced hypo-osmoregulation induced by warm-acclimation in Antarctic fish is mediated by increased gill and kidney Na+/K+-ATPase activities. J Exp Biol 198:2279–2291Google Scholar
  11. 11.
    Eastman JT (1993) Antarctic fish biology. Evolution in a unique environment. Academic Press, New YorkGoogle Scholar
  12. 12.
    Hemmingsen EA, Douglas EL (1970) Respiratory characteristics of the hemoglobin-free fish Chaenocephalus aceratus. Comp Biochem Physiol 33:733–744PubMedCrossRefGoogle Scholar
  13. 13.
    Twelves EL (1972) Blood volume of two Antarctic fishes. Br Antarct Surv Bull 31:85–92Google Scholar
  14. 14.
    Acierno R, Macdonald JA, Tota B (1995) Blood volume in the hemoglobinless Antarctic teleost Chionodraco hamatus (Lönnberg). J Exp Zool 272:407–409CrossRefGoogle Scholar
  15. 15.
    Tota B, Acierno R, Agnisola C (1991) Mechanical performance of the isolated and perfused heart of the haemoglobinless Antarctic icefish Chionodraco hamatus: effects of loading conditions and temperature. Phil Trans Royal Soc London, 332:191–198CrossRefGoogle Scholar
  16. 16.
    Takei Y (1994) Structure and function of natriuretic peptides in vertebrates. Persp Comp Endocrinol 149–154Google Scholar
  17. 17.
    Lang CC, Choy AMJ, Struthers AD (1992) Atrial and brain natriuretic peptides: a dual natriuretic peptide system potentially involved in circulatory homeostasis. Clin Sei 83: 519–527Google Scholar
  18. 18.
    Anand-Srivastava MB, Trachte GJ (1993) Atrial natriuretic factor receptors and signal transduction mechanisms. Pharmacol Rev 45(4):455–497PubMedGoogle Scholar
  19. 19.
    Sakaguchi H, Katafuchi T, Hagiwara H, Takei Y, Hirose S (1993) High-density localization of ANP receptors in chondrocytes of the eel gill cartilage. Am J Physiol 265: R474–R479PubMedGoogle Scholar
  20. 20.
    Katafuchi T, Takashima A, Kashiwagi M, Hagiwara H, Takei Y, Hirose S (1994) Cloning and expression of eel natriuretic-peptide receptor B and comparison with its mammalian counterpart. Eur J Biochem 222:835–842PubMedCrossRefGoogle Scholar
  21. 21.
    Donald JA, Toop T, Evans DH (1994) Localization and analysis of natriuretic peptide receptors in the gills of the toadfish, Opsanus beta (teleostei). Am J Physiol 267:R1437–R1444PubMedGoogle Scholar
  22. 22.
    Duff DW, Olson KR (1992) Atrial natriuretic peptide clearance receptors in trout: effects of receptor inhibition in vivo. J Exp Zool 262:343–346PubMedCrossRefGoogle Scholar
  23. 23.
    Takashima A, Katafuchi T, Shibasaki M, Kashiwagi M, Hagiwara H, Takei Y, Hirose S (1995) Eel natriuretic peptide receptor NPR-C. Cloning, properties, site-directed mutagenesis analysis of the subunit structure, tissue distribution, and regulation of expression. Eur J Biochem 277:673–680CrossRefGoogle Scholar
  24. 24.
    Cerra MC, Canonaco M, Takei Y, Tota B (1996) Characterization of natriuretic peptide binding sites in the heart of the eel, Anguilla anguilla. J Exp Zool 275:27–35CrossRefGoogle Scholar
  25. 25.
    Uva BM, Masini MA, Napoli L, Devecchi M (1993) Immunoreactive atrial natriuretic peptide in Antarctic teleosts. Comp Biochem Physiol A, 104(2): 291–297CrossRefGoogle Scholar
  26. 26.
    Cerra MC, Canonaco M, Tota B (1992) A quantitative autoradiographic study of 125I atrial natriuretic factor in the heart of a teleost fish (Conger conger). J Exp Zool 263:215–219PubMedCrossRefGoogle Scholar
  27. 27.
    Klemola R, Laine M, Weckström M, Vuolteenhao O, Ruskoaho H, Huttunen P, Leppäluoto J (1995) High concentrations of atrial natriuretic peptide and brain natriuretic peptide in rat pericardial fluid and their reduction by reserpine in vivo. Arch Pharmacol 352:331–336CrossRefGoogle Scholar
  28. 28.
    Oehlenschlager WF, Baron DA, Shomer H, Currie MG (1989) Atrial and brain natriuretic peptides share binding sites in the kidney and heart. Eur J Pharmacol 161: 159–164PubMedCrossRefGoogle Scholar
  29. 29.
    Wilcox JN, Augustine A, Goeddel DV, Lowe DG (1991) Differential regional expression of three natriuretic peptide receptor genes within primate tissues. Mol Cell Biol 11: 3454–3462PubMedGoogle Scholar
  30. 30.
    Gunning M, Cuero C, Solomon R, Silva P (1993) C-type natriuretic peptide receptors and signaling in rectal gland of Squalus acanthias. Am J Physiol 264: F300–F305PubMedGoogle Scholar
  31. 31.
    Takei Y, Takano M, Itahara Y, Watanabe TX, Nakajima K, Conklin DJ, Duff DW, Olson KR (1994) Rainbow trout ventricular natriuretic peptide: isolation, sequencing, and determination of biological activity. Gen Comp Endocrinol 96:420–426PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 1998

Authors and Affiliations

  • Maria C. Cerra
    • 1
    • 2
  • Rosa Mazza
    • 1
  • Daniela Pellegrino
    • 1
  • Bruno Tota
    • 1
    • 3
  1. 1.Department of Cell BiologyUniversity of CalabriaArcavacata di RendeItaly
  2. 2.Department of Pharmaco-BiologyUniversity of CalabriaArcavacata di RendeItaly
  3. 3.Zoological Station “A. Dohrn,”Villa ComunaleNapoliItaly

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