The Italian Multicentric Study on Hypertrophic Cardiomyopathy: I. Natural History and Clinical Course of Unselected Patients
In the past 8 years since the last Florence meeting, four major issues have emerged in the field of hypertrophie cardiomyopathy (HCM), namely genetic testing, pacemaker therapy, epidemiological data and outcome studies from unselected populations . Among these, epidemiologic studies have shown that HCM is more common than previously thought, with a prevalence of about 0.2% . Also, in contrast with what was once thought based on selected tertiary referral center populations , the majority of HCM patients in the general population has been shown to be asymptomatic and non-obstructive [1,4]. Further natural history studies are therefore crucial in order to evaluate the clinical outcome and prognosis in unselected HCM populations, and to assess the appropriate strategies for clinical management of the disease. After we reported in 1989 the good clinical outcome of 157 patients with HCM followed at the Careggi Hospital in Florence , a multicentric study was set up including a large study group of patients from 5 non-referral institutions in Central and Northern Italy. The aim of our study was to determine the annual mortality rate for cardiovascular causes, the clinical deterioration rate and the occurrence of cardiovascular events in a large unselected population with HCM.
KeywordsAtrial Fibrillation Hypertrophic Cardiomyopathy Nonsustained Ventricular Tachycardia Italian Multicentric Study Ventricular Outflow Obstruction
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