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Virus Infection in Cardiomyopathies: Brief Overview, Recent Advances

  • S. Tracy
  • N. M. Chapman
Conference paper

Abstract

Viruses are a primary cause of acute inflammatory human heart disease and are believed to contribute significantly as well to the development of dilated cardiomyopathy (DCM) [1–3]. Human enteroviruses seem at present to be the primary viral agents of human viral heart disease. Based upon isolation of virus from diseased human heart tissue, a host of serological studies, and a variety of molecular data, the coxsackie B viruses (CVBs) are the most common enterovirus group implicated as agents of human heart disease [4,5]. However, within the past few years, adenoviruses have also been implicated in pediatric inflammatory heart disease, and it is possible that adenoviruses may be more common agents of heart disease, at least in children, than the enteroviruses [6]. Other viruses (herpesviruses, influenza viruses, HIV) have been implicated as agents of human heart disease but none close to the frequency of either the CVBs or adenoviruses.

Keywords

Dilate Cardiomyopathy Acute Myocarditis Human Enterovirus Infectious cDNA Clone Coronary Sinus Blood 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Martino T, Liu P, Petric M, Sole M (1995) Enteroviral myocarditis and dilated cardiomyopathy: a review of clinical and experimental studies. In: Rotbart H (ed) Human Enterovirus Infections. ASM Press, Washington, D.C.Google Scholar
  2. 2.
    Martino T, Liu P, Sole M (1994) Viral infection and the pathogenesis of dilated cardiomyopathy. Circ Res 74:182–188PubMedCrossRefGoogle Scholar
  3. 3.
    Tracy S, Chapman N, Mahy B (eds) (1997) The Coxsackie B Viruses. Springer-Verlag, Berlin Heidelberg New YorkGoogle Scholar
  4. 4.
    Woodruff J (1980) Viral myocarditis. A review. Am J Pathol 101:425–484Google Scholar
  5. 5.
    Friman G, Wesslen L, Fohlman J et al. (1995) The epidemiology of infectious myocarditis, lymphocytic myocarditis and dilated cardiomyopathy. Eur Heart J 16 [Suppl O]:36–41PubMedCrossRefGoogle Scholar
  6. 6.
    Martin AB, Webber S, Fricker FJ, Jaffe R, Demmier G, Kearney D, Zhang Y_H, Bodurtha J, Gelb B, Ni J, Bricker JT, Towbin JA (1994) Acute myocarditis. Rapid diagnosis by PCR in children. Circulation 90:330–339Google Scholar
  7. 7.
    Tu, Z, Chapman N, Hufnagel G, Tracy S, Romero JR, Barry WH, Zhao L, Currey K, Shapiro B (1995) The cardiovirulent phenotype of coxsackievirus B3 is determined at a single site in the genomic 5’ nontranslated region. J Virol 69:4607–4618PubMedGoogle Scholar
  8. 8.
    Chapman N, Tu Z, Tracy S, Gauntt C (1994) An infectious cDNA copy of the genome of a non-cardiovirulent coxsackievirus B3 strain: its complete sequence analysis and comparison to the genomes of cardiovirulent coxsackieviruses. Arch Virol 135:115–130PubMedCrossRefGoogle Scholar
  9. 9.
    Gieni R, Li Y, HayGlass K (1995) Comparison of [3H] thymidine incorporation with MTT-and MTS-based bioassays for human and murine IL-2 and IL-4 analysis. Tetrazolium assays provide markedly enhanced sensitivity. J Immunol Methods 187:85–93PubMedCrossRefGoogle Scholar
  10. 10.
    Fyfe A, Daly P, Galligan L, Pirc L, Feindel C, Cardella C (1993) Coronary sinus sampling of cytokines after heart transplantation: evidence for macrophage activation and interleukin-4 production within the graft. J Am Coll Cardiol 21:171–176PubMedCrossRefGoogle Scholar
  11. 11.
    Ramsingh A, Araki H, Bryant S, Hixson A (1992) Identification of candidate sequences that determine virulence in Coxsackievirus B4. Virus Res 23:281–292PubMedCrossRefGoogle Scholar
  12. 12.
    Chapman N, Tracy S, Ramsingh A (1997) The genetics of CVB virulence. In: Tracy S, Chapman N, Mahy B (eds) The Coxsackie B Viruses. Current Topics in Microbiology and Immunology vol 223. Springer-Verlag, Berlin Heidelberg New York, pp 227–258Google Scholar

Copyright information

© Springer-Verlag Italia 1998

Authors and Affiliations

  • S. Tracy
  • N. M. Chapman

There are no affiliations available

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