The Use of Magnetic Resonance Imaging to Select Patients for Multiple Sclerosis Clinical Trials

  • J. H. Simon
Conference paper
Part of the Topics in Neuroscience book series (TOPNEURO)


The standard and most common approaches used in the selection of patients for multiple sclerosis (MS) treatment trials have been based primarily on clinical criteria. Entrance and selection criteria typically include disease classification (e.g. relapsing versus secondary progressive MS), an inclusive range of disability scores, the pre-trial exacerbation rate, and age. Today we are at an important junction in trials design, such that magnetic resonance imaging (MRI)-based criteria are recognized as increasingly important additional selection criteria in MS clinical trials.


Multiple Sclerosis Optic Neuritis Magnetic Resonance Imaging Study Enhance Lesion Secondary Progressive Multiple Sclerosis 
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Copyright information

© Springer-Verlag Italia 1999

Authors and Affiliations

  • J. H. Simon
    • 1
  1. 1.Department of RadiologyUniversity of Colorado Health Sciences CenterDenverUSA

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