Standardisation, Optimisation and Organisation of Magnetic Resonance Imaging for Monitoring Clinical Trials
The use of magnetic resonance imaging (MRI) in clinical trials for multiple sclerosis (MS) was pioneered by Paty et al.  at the University of British Columbia, Canada, following studies of the correlation of the MRI appearance of demyelinating lesions with both animal models and postmortem material [2, 3]. Without this ground-breaking work, much of the testing of new therapeutic agents seen today would be severely retarded, with much longer assessment periods, and a much more difficult pathway of the drug from laboratory to market.
KeywordsMagnetic Resonance Imaging Multiple Sclerosis Lesion Volume Multiple Scle Lesion Magnetic Field Gradient
Unable to display preview. Download preview PDF.
- 1.Paty DW, Li DKB, the UBC MS/MRI Study Group, the IFNb Multiple Sclerosis Study Group (1993) Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 43: 662–667PubMedCrossRefGoogle Scholar
- 2.Stewart WA, Hall LD, Berry K, Paty DW (1984) Correlation between NMR scan and brain slice data in multiple sclerosis. Lancet ii: 412Google Scholar
- 12.Thorpe JW, Halpin SF, MacManus DG, et al. (1994) A comparison between fast and conventional spin-echo in the detection of multiple sclerosis lesions. AJNR Am J Neuroradiol 18:959–963Google Scholar
- 16.Barker GJ, Schreiber W, Gass A, et al. (1997) Standardising magnetisation transfer ratio measurements between MR scanners from different manufacturers. In: Proceedings of the International Society of Magnetic Resonance Medicine 3:1556 (abstract) 1556Google Scholar
- 19.Horsfield MA, Larsson HBW, Jones DK, Gass A (1998) Diffusion magnetic resonance imaging in multiple sclerosis. J Neurol Neurosurg Psychiatry S64: 80–84Google Scholar
- 27.Wolinsky JS, Narayana PA (1998) Phase 3 North American trial of roquinimex (linomide) in relapsing-remitting (RR) and secondary progressive (SP) multiple sclerosis (MS): MRI findings. Neurology 50: 4004 (abstract)Google Scholar