Standardisation, Optimisation and Organisation of Magnetic Resonance Imaging for Monitoring Clinical Trials

  • M. A. Horsfield
Conference paper
Part of the Topics in Neuroscience book series (TOPNEURO)


The use of magnetic resonance imaging (MRI) in clinical trials for multiple sclerosis (MS) was pioneered by Paty et al. [1] at the University of British Columbia, Canada, following studies of the correlation of the MRI appearance of demyelinating lesions with both animal models and postmortem material [2, 3]. Without this ground-breaking work, much of the testing of new therapeutic agents seen today would be severely retarded, with much longer assessment periods, and a much more difficult pathway of the drug from laboratory to market.


Magnetic Resonance Imaging Multiple Sclerosis Lesion Volume Multiple Scle Lesion Magnetic Field Gradient 
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Copyright information

© Springer-Verlag Italia 1999

Authors and Affiliations

  • M. A. Horsfield
    • 1
  1. 1.Division of Medical PhysicsUniversity of Leicester, Leicester Royal InfirmaryLeicesterUK

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