Dementias pp 151-171 | Cite as

Frontotemporal Dementia

  • L. Gustafson
  • A. Brun


The principles for classification of organic dementia are based on our present knowledge of its etiology, clinical picture, and pathological characteristics such as the type and predominant location of the brain damage. This paper concerns the clinical and pathological findings in dementia cases with primary degenerative changes within the frontal and temporal lobes and the possibility to differentiate this frontotemporal dementia (FTD) from Alzheimer’s disease (AD) and other dementias. The importance of localized cortical atrophy within the frontal and temporal lobes in dementia was pointed out by Arnold Pick more than 100 years ago [1]. The neuropathological characteristics of this condition were given by Alzheimer [2], who described the ballooned cells and argentophilic inclusion bodies. The clinicopathological entity of this “Pick’s disease” or “lobar atrophy” was delineated by Onari and Spatz [3] and Schneider [4], and further elaborated in a series of important contributions [5, 6, 7, 8, 9].


Frontal Lobe Progressive Supranuclear Palsy Frontotemporal Dementia Progressive Supranuclear Palsy Lobar Atrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Italia 1999

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  • L. Gustafson
  • A. Brun

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