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Dementia with Lewy Bodies

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Dementias

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Abstract

Lewy bodies are intracytoplasmic, eosinophilic intraneuronal inclusion bodies [1]. They contain phosphorylated and non-phosphorylated microfilaments, β-crystalline, ubiquitin and proteinases [2]. They are therefore indicators of cell response to stress and markers for the degradation and excretion of abnormal proteins from the cell. Although Lewy bodies in the substantia nigra were identified as a key neuropathological element of Parkinson’s disease (PD) early in the century, the importance of cortical Lewy bodies as a feature of some cases of dementia has only recently become evident. A series of single case reports and small case series appeared in the literature between the 1960s and the mid-1980s, suggesting that Lewy bodies in the cerebral cortex could be associated with a rare form of dementia [3–6]. Hospital-based postmortem series reporting consecutive dementia cases have subsequently identified cortical Lewy bodies in at least 10% of dementia sufferers [7–10].

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References

  1. Forno LS (1969) Concentric hyalin intraneuronal inclusions of Lewy type in the brains of elderly persons (950 incidental cases). Relationship to parkinsonism. J Am Geriatr Soc 17: 557–575

    CAS  Google Scholar 

  2. Lowe JS, Mayer RJ, London M (1996) Pathological significance of Lewy bodies in dementia. In: McKeith EG, Perry EK (eds) Dementia with Lewy bodies. Cambridge University Press, Cambridge, pp 195–203

    Chapter  Google Scholar 

  3. Woodard JS (1962) Concentric hyaline inclusion body formation in mental disease. Analysing 27 cases. J Neuropathol Exp Neurol 21: 442–449

    Article  PubMed  CAS  Google Scholar 

  4. Yoshimura M (1983) Cortical changes in the parkinsonian brain: a contribution to the delineation of diffuse Lewy body disease. J Neurol 229: 17–32

    Article  PubMed  CAS  Google Scholar 

  5. Kosaka K (1978) Lewy bodies in cerebral cortex: report of 3 cases. Acta Neuropathol (Berl)42: 127–134

    Article  CAS  Google Scholar 

  6. Gibb WRG, Esiri MM, Lees AJ (1987) Clinical and pathological features of diffuse Lewy body disease (Lewy body dementia). Brain 100: 1131–1153

    Article  Google Scholar 

  7. Burns A, Jacoby R, Levy R (1990) Psychiatric phenomena in Alzheimer’s disease. Br J Psychiatry 157: 72–94

    Article  PubMed  CAS  Google Scholar 

  8. Byrne EJ, Lennox G, Lowe J, Goodwin-Austen RB (1989) Diffuse Lewy body disease, clinical features in 15 cases. J Neurol Neurosurg Psychiatry 52: 709–717

    Article  PubMed  CAS  Google Scholar 

  9. Perry RH, Irving D, Blessed G, Fairbairn A, Perry EK (1990) Senile dementia of the Lewy body type: a clinically and neuropathologically distinct form of Lewy body dementia in the elderly. J Neurol Sci 95: 119–139

    Article  PubMed  CAS  Google Scholar 

  10. Hansen LA, Salmon D, Galasko D, Masliah E, Katzman R, DeTeresa R, Thal L, Pay MM, Hofstetter R, Klauber M (1990) The Lewy body variant of Alzheimer’s disease: a clinical and pathological entity. Neurology 40: 1–7

    Article  PubMed  CAS  Google Scholar 

  11. Crystal HA, Dickson DW, Lizadi HE, et al (1990) Antemortem diagnosis of diffuse Lewy body disease. Neurology 40: 1523–1528

    Article  PubMed  CAS  Google Scholar 

  12. McKeith IG, Perry RH, Fairbairn AF, Jabeen S, Perry EK (1992) Operational criteria for senile dementia of Lewy body type (SDLT). Psychol Med 22: 911–922

    Article  PubMed  CAS  Google Scholar 

  13. Byrne EJ, Lennox G, Goodwin-Austen LB (1991) Dementia associated with cortical Lewy bodies: proposed diagnostic criteria. Dementia 2: 283–284

    Google Scholar 

  14. Ballard CG, Mohan RNC, Patel A, Bannister C (1993) Idiopathic clouding of consciousness — do the patients have cortical Lewy body disease? Int J Geriatr Psychiatry 8: 571–576

    Article  Google Scholar 

  15. Shergill S, Mullen E, D’Ath P, Katrona C (1994) What is the clinical prevalence of Lewy body dementia. Int J Geriatr Psychiatry 9: 907–912

    Article  Google Scholar 

  16. Ballard CG, Saad K, Gahir M, Solis M, Coope B, Wilcock G (1995) The prevalence and phenomenology of psychotic symptoms in dementia sufferers. Int J Geriatr Psychiatry 10: 477–485

    Article  Google Scholar 

  17. Dickson DW, Ruan D, Crystal H, Mark MH, Davies P, Kress Y, Yen SH (1991) Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer’s disease: light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD. Neurology 41: 1402–1409

    Article  PubMed  CAS  Google Scholar 

  18. Bancher C, Lassman H, Budka H, Jellinger K, Grundke-Iqbal I, Iqbal K, Wiche G, Scitelberger F, Wisniewski HM (1989) An antigenic profile of Lewy bodies: immunocytochemical indication for protein phosphorylation and ubiquitination. J Neuropathol Exp Neurol 48: 81–93

    Article  PubMed  CAS  Google Scholar 

  19. Pollanen MS, Dickson DW, Bergeron C (1993) Pathology and biology of the Lewy body. J Neurophatol Exp Neurol 52: 183–191

    Article  CAS  Google Scholar 

  20. Masliah E, Mallory M, DeTeresa R, Alford M, Hansen L (1993) Differing patterns of aberrant neuronal sprouting in Alzheimer’s disease with and without Lewy bodies. Brain Res 617: 258–266

    Article  PubMed  CAS  Google Scholar 

  21. Ince PG, Irving D, MacArthur F, Perry RH (1991) Quantitative neuropathological study of Alzheimer-type pathology in the hippocampus: comparison of senile dementia of Alzheimer type, senile dementia of Lewy body type, Parkinson’s disease and non-demented elderly control patients. J Neurol Sci 106: 142–152

    Article  PubMed  CAS  Google Scholar 

  22. Wu E, Lipton RG, Dickson DW (1992) Amyloid angiopathy in diffuse Lewy body disease. Neurology 42: 2131–2135

    Article  PubMed  CAS  Google Scholar 

  23. McKeith IG, Fairbairn AF, Bothwall RA, Moore PB, Ferrier IN, Thompson P, Perry RH (1994) An evaluation of the predictor validity and inter-rater reliability of clinical diagnostic Criteria for SDLT. Neurology 44: 872–877

    Article  PubMed  CAS  Google Scholar 

  24. Galasko D, Katzman R, Salmon DR, Thal LJ, Hanson L (1996) Clinical and neuropathological findings in Lewy body dementias. Brain Cogn 31: 106–175

    Article  Google Scholar 

  25. Klakta LA, Louis ED, Schiffer RB (1996) Psychiatric factors in diffuse Lewy body disease. Findings in 28 pathologically diagnosed cases. Neurology 47: 1148–1152

    Article  Google Scholar 

  26. Cummings JL (1991) Behavioural complications of drug treatment of Parkinson’s disease. J Am Geriatr Soc 39: 708–716

    PubMed  CAS  Google Scholar 

  27. Howard R, Levy R (1994) Charles-Bonnet syndrome plus complex visual hallucinations of Charles Bonnet type in late paraphrenia. Int J Geriatr Psychiatry 9: 399–404

    Article  Google Scholar 

  28. McShane R, Godling K, Reading M, McDonald B, Esiri MM, Hope T (1995) Prospective study of relations between cortical lewy bodies, poor eyesight and hallucinations in Alzheimer’s disease. J Neurol Neurosurg Psychiatry 59: 185–188

    Article  PubMed  CAS  Google Scholar 

  29. Ballard CG, O’Brien J, Coope B, Fairbairn A, Abid F, Wilcock G (1997) A prospective study of psychotic symptoms in dementia sufferers. Int Psychogeriatr 9: 57–64

    Article  PubMed  CAS  Google Scholar 

  30. Cheng A, Ferrier IN, Morris CM, Jabeen S, Sahgal A, McKeith IG, Edwardson JA, Perry EK, Perry RH (1991) Cortical serotonin-S2 receptor binding in Lewy body dementia, Alzheimer’s and Parkinson’s disease. J Neurol Sci 106: 50–55

    Article  PubMed  CAS  Google Scholar 

  31. Langlais PJ, Thal L, Hansen L, Galasko D, Alford M, Masliah E (1993) Neurotransmitters in basal ganglia and cortex of Alzheimer’s disease with and without Lewy bodies. Neurology 43: 1927–1934

    Article  PubMed  CAS  Google Scholar 

  32. Cohen RA, Kaplan RF, Meadows ME, Wilkinson H (1994) Habituation and sensitization of the orienting response following bilateral anterior cingulotomy. Neuropsychologia 32: 609–617

    Article  PubMed  CAS  Google Scholar 

  33. Degos JD, da Fonseca N, Gray F, Cesaro P (1993) Severe frontal syndrome associated with infarcts of the left anterior cingulate gyrus and the head of the right caudate nucleus. A clinico-pathological case. Brain 116: 1541–1548

    PubMed  Google Scholar 

  34. McKeith IG, Fairbairn AF, Perry R, Thompson P, Perry EK (1992b) Neuroleptic sensitivity in patients with senile dementia of Lewy body type. BMJ 305: 653–678

    Article  Google Scholar 

  35. Marshall EF, Perry EK, Perry RH, McKeith IG, Fairbairn AF, Thompson P (1993) Dopamine metabolism in postmortem caudate nucleus in neurdegenerative disorders. Neurosci Res Commun 14: 17–25

    Google Scholar 

  36. Piggott MA, Perry EK, Marshall EF, McKeith IG, Johnson M, Melrose HL, Court JA, Lloyd S, Fairbairn A, Brown A, Thompson P, Perry RH (1998) Nigrostriatal dopaminergic activities in dementia with Lewy bodies in relation to neuroleptic sensitivity: comparisons with Parkinson’s disease. Biol Psychiatry 44: 765–777

    Article  PubMed  CAS  Google Scholar 

  37. Piggott MA, Marshall EF (1996) Neurochemical correlates of pathological and iatrogenic extrapyramidal symptoms. In: McKeith E, Perry E (eds) Recent advances in dementia with Lewy bodies. Cambridge University Press, Cambridge, pp 449–467

    Chapter  Google Scholar 

  38. Förstl H, Burns A, Luthert P, Cairns N, Levy R (1993) The Lewy body variant of Alzheimer’s disease: clinical and pathological findings. Br J Psychol 162: 385–392

    Article  Google Scholar 

  39. Sahgal A, Galloway PH, McKeith IG, Edwardson JA, Lloyd S (1992) A comparative study of attentional deficits in senile dementia of alzheimer’s and Lewy body types. Dementia 3: 350–354

    Google Scholar 

  40. Ballard C, Patel A, Oyebode F, Wilcock G (1996) Cognitive decline in patients with Alzheimer’s disease, vascular dementia and Senile dementia of Lewy body type. Age Ageing 25: 209–213

    Article  PubMed  CAS  Google Scholar 

  41. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261: 921–923

    Article  PubMed  CAS  Google Scholar 

  42. Martins RN, Clarnette R, Fisher C, Broe GA, Brooks WS, Montgomery P, Gandy SE (1995) Apo E genotypes in Australia: roles in early and late onset Alzheimer’s disease and Down’s syndrome. Neuroreport 6: 1513–1516

    Article  PubMed  CAS  Google Scholar 

  43. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Rinnuler JB, Locke PA, Conneally PM, Schmader KE, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1994) Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer’s disease. Nat Genet 7: 180–184

    Article  PubMed  CAS  Google Scholar 

  44. Castano EM, Prelli F, Wisniewski T, Golabek A, Kumar RA, Soto C, Frangione B (1995) Fibrillogenesis in Alzheimer’s disease of the amyloid β peptides and apolipoprotein E. Biochem J 306: 599–604

    PubMed  CAS  Google Scholar 

  45. Harrington CR, Louwagie J, Rossau R, Vanmechelen E, Perry RH, Perry EK, Xuereb JH, Roth M, Wischik CM (1994) Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Significance for etiological theories of Alzheimer’s disease. Am J Pathol 145: 1472–1484

    PubMed  CAS  Google Scholar 

  46. Morris CM, Massey HM, Benjamin R, Leake A, Broadbent C, Griffiths M, Lamb H, Brown A, Ince PG, Tyrer S, Thompson P, McKeith IG, Edwardson JA, Perry RH, Perry EK (1996) Molecular biology of APO E alleles in Alzheimer’s and non-Alzheimer’s dementias. J Neural Transm Suppl 47: 205–218

    Article  PubMed  CAS  Google Scholar 

  47. Koller WC, Glatt SL, Hubble JP, Paolo A, Tröster AI, Handler MS, Horvat, RT, Martin C, Schmidt K, Karst A, Wijsman EM, Yu C-E, Schellenberg GD (1995) Apolipoprotein E genotypes in Parkinson’s disease with and without dementia. Ann Neurol 37: 242–245

    Article  PubMed  CAS  Google Scholar 

  48. Saitoh T, Xia Y, Chen X, Masliah E, Galasko D, Shults C, Thal LJ, Hansen LA, Katzman R (1995) The CYP2D6B allele is overepresented in the Lewy body variant of Alzheimer’s disease. Ann Neurol 37: 110–112

    Article  PubMed  CAS  Google Scholar 

  49. Brøsen K, Gram LF (1989) Clinical significance of the sparteine/debrisoquine oxidation polymorphism. Eur J Clin Pharmacol 36: 537–547

    Article  PubMed  Google Scholar 

  50. Gonzalez FJ, Skoda RC, Kimura S, Demierre A (1988) Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature 331: 442–446

    Article  PubMed  CAS  Google Scholar 

  51. Kurth MC, Kurth JH (1993) Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson’s disease. Am J Med Genet 48: 166–168

    Article  PubMed  CAS  Google Scholar 

  52. Kamboh MI, Shanghera DK, Ferrel RE, DeKosky ST (1995) APO E4-associated Alzheimer’s disease risk modified by αl-antichymotrypsin polymorphism. Nature Genet 10: 486–488

    Article  PubMed  CAS  Google Scholar 

  53. Wragg M, Hutton M, Talbot C (1996) Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer’s disease. Alzheimer’s Disease Collaborative Group. Lancet 347: 509–512

    Article  PubMed  CAS  Google Scholar 

  54. Wilcock GK (1990) Tetrohydro amino acridine and Alzheimer’s disease. BMJ 300: 939

    Google Scholar 

  55. Levy R, Eagger S, Griffiths M (1994) Lewy bodies and response to tacrine. Lancet 343: 176

    Article  PubMed  CAS  Google Scholar 

  56. Schneider LS, Pollock VE, Lyness SA (1990) A meta analysis of controlled trials of neuroleptic treatment in dementia. J Am Geriatr Soc 38: 553–563

    PubMed  CAS  Google Scholar 

  57. Auzou P, Cote L, Fahn S (1995) Clozapine Parkinson’s disease. Lancet 345: 516–517

    Google Scholar 

  58. Lee H, Cooney JM, Lewlor BA (1994) Case report: the use of risperidone, an atypical neuroleptin Lewy body disease. Int J Geriatr Psychiatry 9: 415–417

    Article  Google Scholar 

  59. McKeith IG, Ballard CG, Harrison RWS (1995) Neuroleptic sensitivity to risperidone in Lewy body dementia. Lancet 346: 699

    Article  PubMed  CAS  Google Scholar 

  60. Cummings JL, Gorman DG, Shapira J (1993) Physostigmine ameliorates the delusions of Alzheimer’s disease. Biol Psychiatry 33: 536–541

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. C. Ballard
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  2. C. Morris
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  3. M. Piggott
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Editor information

Editors and Affiliations

  1. Institute of Pharmacology, University of Pavia, Viale Taramelli 14, 27100, Pavia, Italy

    Stefano Govoni

  2. IRCCS “S. Giovanni di Dio”, “S. Cuore-Fatebenefratelli” Institute, Via Pilastroni 4, 25125, Brescia, Italy

    Stefano Govoni

  3. Consultant Office of Research Policy and Strategy Coordination of WHO, University of Milan, Italy

    Carla Liana Bolis

  4. Geriatric Research Group, Via Romanino 1, 25122, Brescia, Italy

    Marco Trabucchi

  5. Department of Neurosciences, University of Rome “Tor Vergata”, Rome, Italy

    Marco Trabucchi

  6. Alzheimer’s Unit, IRCCS “S. Giovanni di Dio”, “S. Cuore-Fatebenefratelli” Institute, Via Pilastroni 4, 25125, Brescia, Italy

    Marco Trabucchi

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© 1999 Springer-Verlag Italia

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Ballard, C., Morris, C., Piggott, M. (1999). Dementia with Lewy Bodies. In: Govoni, S., Bolis, C.L., Trabucchi, M. (eds) Dementias. Springer, Milano. https://doi.org/10.1007/978-88-470-2149-5_6

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  • DOI: https://doi.org/10.1007/978-88-470-2149-5_6

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0048-3

  • Online ISBN: 978-88-470-2149-5

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