Epidemiology of Gastroesophageal Reflux in Asthma

  • R. W. Dal Negro
  • P. Turco


Gastroesophageal reflux (GER) represents a well-established digestive disorder which was identified by gastroenterologists long ago. Hypothesis of the occurrence of GER-related respiratory complications, particularly asthma symptoms, was frequently regarded with scepticism in the past. Similarly, respiratory complications of GER were only seen as negligible clinical suggestions.


Hiatal Hernia Gastroesophageal Reflux Lower Esophageal Sphincter Asthma Symptom Acid Regurgitation 


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  1. 1.
    Osier WB (1892) The principles of medicine. Appleton, New YorkGoogle Scholar
  2. 2.
    Mermod E (1887) Dilatation diffuse de l’oesophage. Rev Med Suisse Rom, quoted in N Engl J Med 245:441Google Scholar
  3. 3.
    Vinson EP (1924) Diagnosis and treatment of cardiospasm. JAMA 82:859–863CrossRefGoogle Scholar
  4. 4.
    Mendelson CL (1946) The aspiration of stomach contents into the lungs during obstetric anesthesia. Am J Obstet Gynecol 52:191–194PubMedGoogle Scholar
  5. 5.
    Clemecon GH, Sterman P (1961) Hiatal hernia in bronchial asthma: the importance of concomitant pulmonary emphysema. Gastroenterology 95:110–115CrossRefGoogle Scholar
  6. 6.
    Darling DB, McCauley RGK, Leonidas JC, Schwartz AM (1978) Gastroesophageal reflux in infants and children: correlation of radiological severity and pulmonary pathology. Pediatr Radiol 127:735–740Google Scholar
  7. 7.
    Mays EE (1976) Intrinsic asthma in adults: association with gastroesophageal reflux. JAMA 236:2626–2628PubMedCrossRefGoogle Scholar
  8. 8.
    Overholt RH, Ashraf MM (1966) Esophageal reflux as a trigger in asthma. N Y State J Med 66:3030–3032PubMedGoogle Scholar
  9. 9.
    Davis MV (1969) Evolving concepts regarding hiatal hernia and gastroenterological reflux. Ann Thorac Surg 1:120–123CrossRefGoogle Scholar
  10. 10.
    Babb RR, Notarangelo J, Smith VM (1970) Wheezing: a clue to gastroenterological reflux. Am J Gastroenterol 53:230–233PubMedGoogle Scholar
  11. 11.
    Danus O, Cesar C, Larrain A, Pope II CE (1976) Esophageal reflux: an unrecognised cause of recurrent obstructive bronchitis in children. J Pediatr 89:220–224PubMedCrossRefGoogle Scholar
  12. 12.
    Giudicelli R, Dupin B, Surpas P, et al (1990) Reflux gastro-esophagien et manifestations respiratoires: attitude diagnostique, indications thérapeutiques et résultats. Ann Chir 44:552–554PubMedGoogle Scholar
  13. 13.
    Pasquis P, Tardiff C, Nouvet G (1983) Reflux gastroesophagien et affections respiratoires. Bull Eur Physiopathol Resp 19:645–658Google Scholar
  14. 14.
    Perrin-Fayolle M, Bel A, Kofman J, et al (1980) Asthma et reflux gastro-esophagien: résultats d’une enquête portant sur 150 cas. Poumon Coeur 36:225–230PubMedGoogle Scholar
  15. 15.
    Ramon P, Mallart-Voisin A, Wallaert B, et al (1998) Association asthma et reflux gastroesophagien: stratégie des examens complémentaires. Rev Med Respir 2:289–294Google Scholar
  16. 16.
    Pin I, Cignoux C, Delmas-Vassort D, et al (1989) Relation chronologique entre reflux gastro-esophagien et asthma. Rev Mal Resp 6:255–260Google Scholar
  17. 17.
    Goldman JM, Bennet JR (1990) Gastro-esophageal reflux and asthma; a common association, but of what clinical importance? Gut 31:1–3PubMedCrossRefGoogle Scholar
  18. 18.
    Ekstrom T, Tibbling L (1987) Gastroesophageal reflux and the triggering of bronchial asthma: negative report. Eur J Respir Dis 71:177–180PubMedGoogle Scholar
  19. 19.
    Sontag SJ, O’Connell S, Khandelwal S, et al (1990) Most asthmatics have gastroesophageal reflux with or without bronchodilator therapy. Gastroenterology 99:613–620PubMedGoogle Scholar
  20. 20.
    Mansfield LE, Stein MR (1978) Gastroesophageal reflux and asthma: a possible reflex mechanism. Ann Allergy 41:224–226PubMedGoogle Scholar
  21. 21.
    Pellegrini CA, DeMeester TR, Johnson LF, et al (1979) Gastroesophageal reflux and pulmonary aspiration: incidence, functional abnormality, and results of surgical therapy. Surgery 86:110–119PubMedGoogle Scholar
  22. 22.
    Hughes DM, Spier S, Rivlin J, Levison H (1983) Gastroesophageal reflux during sleep in asthmatic patients. J Pediatr 102:666–672PubMedCrossRefGoogle Scholar
  23. 23.
    Donald IP, Ford GA, Wilkinson SP (1987) Is 24-hour ambulatory oesophageal pH monitoring useful in a district general hospital? Lancet 1:89–92PubMedCrossRefGoogle Scholar
  24. 24.
    Jolley SG, Herbst JJ, Johnson DG, et al (1981) Esophageal pH monitoring during sleep identifies children with respiratory symptoms from gastroesophageal reflux. Gastroenterology 80:1501–1506PubMedGoogle Scholar
  25. 25.
    Pomari C, Micheletto C, Dal Negro R (1994) Bronchial asthma and gastroesophageal reflux: an epidemiological investigation. Preliminary results. Eur Respir J 7(Suppl 18):15Google Scholar
  26. 26.
    De Meester TR, Wang C, Wesley JA, et al (1980) Technique, indications and clinical use of 24 hour esophageal monitoring. J Thorac Cardiovasc Surg 79:656–670Google Scholar
  27. 27.
    Sontag SJ, Underwood M, Brant R, et al (1992) Prevalence of esophagitis in asthmatics. Gut 33:872–876PubMedCrossRefGoogle Scholar
  28. 28.
    Field SK, Underwood M, Brant R, et al (1996) Prevalence of gastroesophageal reflux symptoms in asthma. Chest 106:316–322CrossRefGoogle Scholar
  29. 29.
    Irwin RS, Curley FJ, French CL (1993) Difficult-to-control asthma: contributing factors and outcome of a systematic management protocol. Chest 103:1662–1669PubMedCrossRefGoogle Scholar
  30. 30.
    Harding SM, Richter JE (1997) The role of gastroesophageal reflux in chronic cough and asthma. Chest 111:1389–1402PubMedCrossRefGoogle Scholar
  31. 31.
    Sontag SJ (1997) Gastroesophageal reflux and asthma. Am J Med 103:84s-90sGoogle Scholar
  32. 32.
    Goyal RK, Rattan S (1978) Neurohumoral, hormonal, and drug receptors for the lower esophageal sphincter. Gastroenterology 74:598–602PubMedGoogle Scholar
  33. 33.
    Stein MR, Towner TG, Weber RW, et al (1980) The effect of theophylline on the lower esophageal sphincter pressure. Ann Allergy 45:238–241PubMedGoogle Scholar
  34. 34.
    Berquist WE, Rachelefsky GS, Kadden M, et al (1981) Effect of theophylline on gastroesophageal reflux in normal adults. J Allergy Clin Immunol 67:407–411PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 1999

Authors and Affiliations

  • R. W. Dal Negro
    • 1
  • P. Turco
    • 1
  1. 1.Lung DepartmentBussolengo General HospitalBussolengo (Verona)Italy

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