The Role of Respiratory Drugs in Gastroesophageal Reflux

  • M. Cazzola
  • S. Centanni
  • M. G. Matera
  • R. W. Dal Negro


Most adult asthmatics have abnormal gastroesophageal reflux manifested by increased reflux frequency, delayed acid clearance during the day and night, and diminished lower oesophageal sphincter pressure; this happens regardless of the use of bronchodilator therapy [1]. Epidemiological evidence for the association between gastroesophageal reflux and asthma suggests that, quite apart from the need for bronchodilators, about three-fourths of asthmatics have acid gastroesophageal reflux, increased frequency of reflux episodes or heartburn, and 40% have reflux oesophagitis [2].


Lower Esophageal Sphincter Reflux Episode Nedocromil Sodium Lower Oesophageal Sphincter Tachykinin Receptor 
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Copyright information

© Springer-Verlag Italia 1999

Authors and Affiliations

  • M. Cazzola
    • 1
  • S. Centanni
    • 2
  • M. G. Matera
    • 1
  • R. W. Dal Negro
    • 3
  1. 1.Clinical Pharmacology Unit and Respiratory Pharmacology Centre, Salvatore Maugeri FoundationIRCCS, Rehabilitation InstituteVeruno (Novara)Italy
  2. 2.Institute of Respiratory DiseasesUniversity of MilanMilanItaly
  3. 3.Lung DepartmentBussolengo General HospitalBussolengo (Verona)Italy

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