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The Esophageal Scintiscan

  • M. Gasparini
  • A. Bruno
  • P. Gerundini

Abstract

Despite advances in medical imaging techniques, such as computed tomography, ultrasound and magnetic resonance, nuclear medicine remains a growing speciality. The clinical practice of nuclear medicine is based on the use of radioactive materials (radionuclides) for the purposes of diagnosis and therapy. This technique is noninvasive and safe; in the majority of cases the administration of diagnostic doses of radiolabeled tracers results in no more radiation exposure than X-ray procedures. The behaviour of a biological substance of interest may be studied by introducing a small quantity of the tracer in a suitably radiolabeled form. The introduction of the tracer should not affect the behaviour of the substance under investigation, there must be stable attachment of the radiolabel to the parent molecule, and the radiolabel should be easily and accurately detected.

Keywords

Lower Esophageal Sphincter Lower Esophageal Sphincter Pressure Reflux Event Esophageal Motility Disorder Diffuse Esophageal Spasm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Kazem I (1972) A new scintigraphic technique for the study of the esophagus. AJR Am J Roentgenol 115:681–688Google Scholar
  2. 2.
    Ham HR, Piepsz A, Georges B, et al (1984) Quantitation of esophageal transit by means of Kr-81m. Eur J Nucl Med 9:362–365PubMedCrossRefGoogle Scholar
  3. 3.
    Tatsch K, Schroettle U, Kirsch CM (1991) Multiple swallow test for the quantitative and qualitative evaluation of esophageal motility disorders. J Nucl Med 32:1365–1370PubMedGoogle Scholar
  4. 4.
    Steffey DL, Wahl RL, Shapiro B (1986) Diabetic oesophagoparesis: assessment by solid phase radionuclide scintigraphy. Nucl Med Commun 7:165–171PubMedCrossRefGoogle Scholar
  5. 5.
    Holloway RH, Krosing G, Lange RC, et al (1983) Radionuclide esophageal emptying of a solid meal to quantitate results of therapy in achalasia. Gastroenterology 84:771–776PubMedGoogle Scholar
  6. 6.
    Tolin RD, Malmud LS, Reilly J, Fisher RS (1979) Esophageal scintigraphy to quantitate esophageal transit (quantitation of esophageal transit). Gastroenterology 76:1402–1408PubMedGoogle Scholar
  7. 7.
    Styles CB, Holt S, Bowles KL, Hopper R (1984) Esophageal transit scintigraphy — a cautionary note. J Can Assoc Radiol 35:31–33PubMedGoogle Scholar
  8. 8.
    Carrette S, Lacourciere Y, Lavoie S, Halle P (1985) Radionuclide esophageal transit in progressive systemic sclerosis. J Rheum 12:478–481Google Scholar
  9. 9.
    Russell COH, Hill LD, Holmes ER, et al (1981) Radionuclide transit: a sensitive screening test for esophageal dysfunction. Gastroenterology 80:887–892PubMedGoogle Scholar
  10. 10.
    Klein HA, Wald A (1984) Computer analysis of radionuclide esophageal transit studies. J Nucl Med 25:957–964PubMedGoogle Scholar
  11. 11.
    Klein HA (1995) Esophageal transit scintigraphy. Semin Nucl Med 4:306–317Google Scholar
  12. 12.
    Lamas-Elvira JM, Martinez-Peredes M, Sopena-Monforte M, et al (1986) Value of radionuclide oesophageal transit in studies of function dysphagia. Br J Radiol 59:1073–1078CrossRefGoogle Scholar
  13. 13.
    Svedberg JB (1982) The bolus transport diagram: a functional display method applied to oesophageal studies. Clin Phys Physiol Meas 3:267–272PubMedCrossRefGoogle Scholar
  14. 14.
    Rozen P, Gelfond M, Zaltaman, S, Baron J, Gilat T (1982) Dynamic, diagnostic, and pharmacological radionuclide studies of the esophagus in achalasia. Radiology 144:587–590PubMedGoogle Scholar
  15. 15.
    DeCaesteker JS, Blackwell JN, Adam RD, et al (1986) Clinical value of radionuclide esophageal transit measurement. Gut 27:659–666CrossRefGoogle Scholar
  16. 16.
    Richter JE, Castell DO (1984) Diffuse esophageal spasm: a reappraisal. Ann Intern Med 100:242–245PubMedGoogle Scholar
  17. 17.
    Blackwell J, Haanan WWJ, Adam RD, Heading RC (1984) Radionuclide transit studies in the detection of oesophageal dysmotility. Gut 24:421–426CrossRefGoogle Scholar
  18. 18.
    Richter JE, Wu WC, Cowan RJ, Ott DJ, Blackwell JN (1987) Letter to the editor: nutcracker esophagus. Dig Dis Sci 30:188–190CrossRefGoogle Scholar
  19. 19.
    Richter JE, Wu WC, Ott DJ, Chen YM (1987) “Nutcracker” esophagus: diagnosis with radionuclide esophageal scintigraphy versus manometry. Radiology 164:877–879 (letter)Google Scholar
  20. 20.
    Benjamin SB, Gerhardt DC, Castell DO (1979) High amplitude, peristaltic esophageal contractions associated with chest pain and/or dysphagia. Gastroenterology 77:478–483PubMedGoogle Scholar
  21. 21.
    Richter JE, Blackwell JN, Wu WC, et al (1987) Relationship of radionuclide liquid bolus transport and esophageal manometry. J Lab Clin Med 109:217–224PubMedGoogle Scholar
  22. 22.
    Drane WE, Johnson DA, Hagan DP, Cattau EL (1987) “Nutcracker” esophagus: diagnosis with radionuclide esophageal scintigraphy versus manometry. Radiology 163:33–37Google Scholar
  23. 23.
    Mughal MM, Marples M, Bancewicz J (1986) Scintigraphic assessment of esophageal motility: what does it show and how reliable is it? Gut 27:946–953PubMedCrossRefGoogle Scholar
  24. 24.
    Drane WE, Karvelis K, Johnson DA, et al (1986) Progressive systemic sclerosis: radionuclide esophageal scintigraphy and manometry. Radiology 160:73–76PubMedGoogle Scholar
  25. 25.
    Horowitz M, McNeil JD, Maddern JG, et al (1986) Abnormalities of gastric and esophageal emptying in polymyositis and dermatomyositis. Gastroenterology 90:434–439PubMedGoogle Scholar
  26. 26.
    Eckern VF, Nix W, Kraus W, Bohl J (1986) Esophageal motor function in patients with muscular dystrophy. Gastroenterology 90:628–630Google Scholar
  27. 27.
    Russel COH, Gannan FR, Coatsworth J, et al (1983) Relationship among esophageal dysfunction, diabetic gastroenteropathy and peripheral neuropathy. Dig Dis Sci 28:289–293CrossRefGoogle Scholar
  28. 28.
    Fisher RS, Malmud LS, Roberts GS, Lobis IF (1976) Gastroesophageal (GE) scinti-scanning to detect and quantitate GE reflux. Gastroenterology 70:301–308PubMedGoogle Scholar
  29. 29.
    Velasco N, Pope CE, Gannan RM, et al (1984) Measurement of esophageal reflux by scintigraphy. Dig Dis Sci 11:977–982CrossRefGoogle Scholar
  30. 30.
    Heyman S, Kirkpatrick, JA, Winter HS, Treves S (1979) An improved radionuclide method for the diagnosis of gastroesophageal reflux and aspiration in children (milk scan). Radiology 131:479–482PubMedGoogle Scholar
  31. 31.
    Wu WC (1990) Ancillary test in the diagnosis of gastroesophageal reflux disease. In: McCallum RW, Mittal RK (eds) Gastroenterology clinics of North America, vol. 19. WB Saunders, Philadelphia, 671–682Google Scholar
  32. 32.
    Dalla Vecchia LK, Grosfeld JL, West KW, et al (1997) Reoperation after Nissen fundoplication in children with gastroesophageal reflux. Experience with 130 patients. Ann Surg 226:315–323CrossRefGoogle Scholar
  33. 33.
    Sondheimer JM (1988) Gastroesophageal reflux: update on pathogenesis and diagnosis. Pediatr Clin N Am 35:103–153Google Scholar
  34. 34.
    Arasu TS, Wyllie R, Fitzgerald JF, et al (1980) Gastroesophageal reflux in infants and children: comparative accuracy of diagnostic methods. J Pediatr 96:798–803PubMedCrossRefGoogle Scholar
  35. 35.
    Malmud LS, Fisher RS (1988) Scintigraphic evaluation of esophageal transit, gastroesophageal reflux, and gastric emptying. In: Gottschalk A, Hoffer PB, Potchen EJ (eds) Diagnostic nuclear medicine, 2nd edn. Williams & Wilkins, Baltimore, 663–683Google Scholar
  36. 36.
    Fisher RS, Malmud LS (1980) Functional scintigraphy: diagnostic applications in gastroenterology. In: Berk JE (ed) Developments in digestive disease. Lea & Febiger, Philadelphia, 139–164Google Scholar
  37. 37.
    Kaul B, Petersen H, Grette K, Erichsen H, Myrvold HE (1985) Scintigraphy, pH measurement, and radiography in the evaluation of gastroesophageal reflux. Scand J Gastroenterol 20:289–294PubMedCrossRefGoogle Scholar
  38. 38.
    Hoffman GC, Vansant JH (1979) The gastroesophageal scintiscan. Arch Surg 114:727–728PubMedCrossRefGoogle Scholar
  39. 39.
    Shay SS, Eggli D, Johnson L (1991) Simultaneous esophageal pH monitoring and scintigraphy during the postprandial period in patients with severe reflux esophagitis. Dig Dis Sci 36:558–564PubMedCrossRefGoogle Scholar
  40. 40.
    Rosen P, Treves ST (1985) Gastroesophageal reflux and gastric emptying. In: Treves ST (ed) Pediatric nuclear medicine. Springer, Berlin Heidelberg New York, 171–177Google Scholar
  41. 41.
    Heyman S, Respondek M (1989) Detection of pulmonary aspiration in children by radionuclide salivagram. J Nucl Med 30:697–699PubMedGoogle Scholar
  42. 42.
    Blumhagen JD, Rudd TG, Christie DL (1980) Gastroesophageal reflux in children: radionuclide gastroesophagography. AJR Am J Roentgenol 135:1001–1004PubMedGoogle Scholar
  43. 43.
    Heyman S (1985) Pediatric nuclear gastroenterology: evaluation of gastroesophageal reflux and gastrointestinal bleeding. In: Freeman LM, Weissmann HS (eds) Nuclear medicine annual 1985. Raven, New York, 33–53Google Scholar
  44. 44.
    Piepsz A, Georges B, Rodeschj P, Cadranel S (1982) Gastroesophageal scintiscanning in children. J Nucl Med 23: 631–632PubMedGoogle Scholar
  45. 45.
    Devos PG, Forgert P, DeRoo M, et al (1979) Scintigraphic evaluation of gastrointestinal reflux (GER) in children. J Nucl Med 30:636 (abstract)Google Scholar
  46. 46.
    Piepsz A, Georges B, Perlmutter N (1981) Gastro-oesophageal scintiscanning in children. Pediatr Radiol 11:71–74PubMedCrossRefGoogle Scholar
  47. 47.
    McVeagh P, Howman-Giles R, Kempt A (1987) Pulmonary aspiration studied by radionuclide milk scanning and barium swallow roentgenography. Am J Dis Child 141:917–921PubMedGoogle Scholar
  48. 48.
    Coben RM, Weintraub A, DiMarino AJ, Cohen S (1994) Gastroesophageal reflux during gastrostomy feeding. Gastroenterology 106:13–18PubMedGoogle Scholar
  49. 49.
    Peracchia A, Bonavina L, Name S, Segalin A, Antoniazzi L, Marotta G (1988) Minimally invasive surgery for Zenker diverticulum. Analysis of results in 95 consecutive patients. Arch Surg 133:695–700Google Scholar
  50. 50.
    Marotta G, Bonavina L, Voltini F, et al (1997) Radionuclide pharyngo-esophageal transit study before and after transoral Zenker’s diverticulum-esophagostomy. Eur J Nucl Med 24:1023Google Scholar
  51. 51.
    Marotta G, Bonavina L, Voltini F, et al (1998) Radionuclide assessment of pharyngo-esophageal emptying before and after transoral Zenker’s diverticulum-esophagostomy. J Nucl Med 39:58PGoogle Scholar
  52. 52.
    Ziessman HA (1996) The gastrointestinal tract. In: Harbert JC, Eckelman WC, Neumann RD (eds) Nuclear medicine. Thieme, New York, 585–649Google Scholar
  53. 53.
    Castronovo FP (1986) Gastroesophageal scintiscanning in a pediatric population: dosimetry. J Nucl Med 27:1212–1214PubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia 1999

Authors and Affiliations

  • M. Gasparini
    • 1
  • A. Bruno
    • 1
  • P. Gerundini
    • 1
  1. 1.Nuclear Medicine DepartmentIRCCS Ospedale MaggioreMilanItaly

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