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Abstract

Albumin is a small highly symmetric, slightly heterogeneous protein weighting 67,000 D with a high cysteine content, composed by 584 aminoacids residues stabilized by 17 internal disulfide bridges. The complete aminoacid sequence maintains high homology through the species [1] and in humans, a relatively high polimorphism is present [2]. In the human genomic it has been found only one copy of the albumin gene on chromosome 4 in bands q11–22 [3].

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References

  1. Dugaiczyk A, Law SW, Dennison OE (1982) Nucleotide sequence and the encoded amino acids of human serum albumin mRNA. Proc Natl Acad Sci USA 79:71–75

    Article  PubMed  CAS  Google Scholar 

  2. Carlson P, Sakamoto Y, Laurell C et al (1992) Alloalbuminemia in Sweden: Structural study and phenotypic distribution of nine albumin variants. Proc Natl Acad Sci USA 89:8225–8229

    Article  PubMed  CAS  Google Scholar 

  3. Peters Jr (1985) The serum albumin. Adv Prot Chem 37:161–245

    Article  CAS  Google Scholar 

  4. Urban J, Inglis AS, Edwards K et al (1974) Chemical evidence for the difference between albumins from microsomes and serum and a possible precursor product relationship. Biochem Biophys Res Commun 61(2):494–501

    Article  PubMed  CAS  Google Scholar 

  5. Sgouris JT, Rene A (eds) Proceedings of the Workshop on Albumin, 1975. Bethesda, Mid, National Heart and Lung Institute 1976, US Dept of Health, Education, and Welfare publication NIH 76–925

    Google Scholar 

  6. Tullis JL (1977) Albumin. Background and use. JAMA 237:355–360

    Article  PubMed  CAS  Google Scholar 

  7. Simonescu N (1979) The microvascular endothelium: Segmental differentiations; transcytosis, selective distribution of anionic sites. In: Weissmann G, Samuelson B, Paoletti R (eds) Advance in Inflammation Research. Vol 1. Raven Press, NY, p 61

    Google Scholar 

  8. Watkins S, Madison J, Galliano M et al (1994) Analbuminemia: Three cases resulting from different point mutations in the albumin gene. Proc Natl Acad Sci USA 91:9417–9421

    Article  PubMed  CAS  Google Scholar 

  9. Falkenberg C, Bjork L, Akerstrom B (1992) Localization of the binding site for streptococcal proteins G on human serum albumin. Identification of a 5.5-kilodalton protein G binding albumin fragment. Biochemistry 31:14551–14557

    Article  Google Scholar 

  10. Grootendorst AF, van Wilgenburg MG, de Laat PH et al (1988) Albumin abuse in intensive care medicine. Intens Care Med 14:554–557

    Article  CAS  Google Scholar 

  11. Grunett A (1991) Osmometrie und Onkometrie in der intensivmedizinischen Diagnostik und Therapie. Schweiz. Z Milit Med 68:69–73

    Google Scholar 

  12. James WPT, Hay AM (1988) Albumin metabolism: effect of albumin supplementation during parenteral nutrition on hospital morbidity. Crit Care Med 16:1177–1182

    Article  Google Scholar 

  13. Rothschild MA, Oratz M, Mongelli J (1968) Effects of a short-term fast on albumin synthesis: Studies in vivo, in the perfused liver, and on amino acid incorporation by hepatic microsomes. J Clin Invest 47:2591

    Article  PubMed  CAS  Google Scholar 

  14. Mosnage HJ, Janssen JAM, Franssen JH et al (1987) Study of the molecular mechanism of decreased liver synthesis of albumin in inflammation. J Clin Invest 79:1635–1641

    Article  Google Scholar 

  15. Saunders LW, Schmidt BJ, Mallona RL et al (1987) Secretion of human serum albumin from Bacillus subtilis. J Bacteriol 169:2917

    PubMed  CAS  Google Scholar 

  16. Cohn EJ, Strong LE, Hughes WL Jr et al (1946) Preparation and properties of serum and plasma proteins. IV. A system for the separation into fractions of the proteins and lipoprotein components of biological tissues and fluids. J Am Chem Soc 68:459

    Article  PubMed  CAS  Google Scholar 

  17. Erstad BL, Gales B, Rappaport WD (1991) The use of albumin in clinical practice. Arch Intern Med 151:901–911

    Article  PubMed  CAS  Google Scholar 

  18. Swisher SN (ed) Report of Panel 6 on safety and efficacy of blood and blood derivatives. Bureau of Biologies, Food and Drug Administration. The Federal Register 1980

    Google Scholar 

  19. Bowman JM (1995) Hemolytic disease of the fetus and newborn. 1995 Conn’s Current Ther (Rakel RE, Ed) Saunders, Philadelphia 329–334

    Google Scholar 

  20. Grant JP (1994) Nutritional support in critically ill patients. Ann Surg 220:610–616

    Article  PubMed  CAS  Google Scholar 

  21. Gines P, Arroyo V, Vargas V et al (1991) Paracentesis with intravenous infusion of albumin as compared with peritoneovenous shunting in cirrhosic with refractory ascites. New Engl J Med 325:829–835

    Article  PubMed  CAS  Google Scholar 

  22. Finkelstein JL, Schwartz SB, Madden MR, et al (1992) Pediatric burns: An overview. In: Di Maio (ed) Pediatric emergency medicine. Ped Clin North America 39:1145–1164

    Google Scholar 

  23. James WPT, Hay AM (1968) Albumin metabolism: Effect of the nutritional state and the dietary protein intake. J Clin Invest 47:1958–1972

    Article  PubMed  CAS  Google Scholar 

  24. Waterhouse C, Bassett SH, Holler J (1949) Metabolic studies on protein depleted patients receiving a large part of their nitrogen intake from human serum albumin administered intravenously. J Clin Invest 28:245

    Article  CAS  Google Scholar 

  25. Pattison CP, Klein CA, Leger RT et al (1976) Field studies of type B hepatitis associated with transfusion of plasma protein fraction. In: Sgouris JT, Rene A (eds) Proceedings of the Workshop on Albumin, p 315

    Google Scholar 

  26. Wells MA, Wittek AE, Epstein JS et al (1986) Inactivation and partition of T-cell lymphotrophic virus, type III, during ethanol fractionation of plasma. Transfusion 26:210–215

    Article  PubMed  CAS  Google Scholar 

  27. Alving BM, Hojima Y, Pisano JJ et al (1978) Hypotension associated with prekallikrein activator (Hageman-factor fragments) in plasma protein fraction. N Engl J Med 299:66

    Article  PubMed  CAS  Google Scholar 

  28. Maharaj D, Fell GS, Boyce BF et al (1987) Aluminium bone disease in patients receiving plasma exchange with contaminated albumin. Brit Med J 295:693–696

    Article  CAS  Google Scholar 

  29. Recknagel S, Bratter P, Crissafidou A et al (1994) Parenteral aluminum loading in critical care medicine part I: Aluminum content of infusion solutions and solutions for parenteral nutrition. Infusionssther Transfusionsmed 21:266–273

    CAS  Google Scholar 

  30. Development Task Force of the College of American Pathologists (1994) Practice parameters for the use of fresh-frozen plasma, cryoprecipitate, and platelet administration practice guidelines. JAMA 271:777

    Article  Google Scholar 

  31. Devine P, Linden JV, Hoffstadter LK et al (1993) Blood donor-, apheresis-, and transfusion-related activities: results of the 1991 American Association of Blood Banks Institutional Membership Questionnaire. Transfusion 33:779

    Article  PubMed  CAS  Google Scholar 

  32. Vermeulen LC, Ratko TA, Erstad BL et al (1995) A paradigm for Consensus. The University hospital consortium guidelines for the use of albumin, nonprotein colloid and crystalloid solutions. Arch Intern Med 155:373–379

    Article  PubMed  Google Scholar 

  33. Yim JM, Vermeulen LV, Erstad BI et al (1995) Albumin and non protein colloid solution use in US academic health centers. Arch Intern Med 155:2450–2455

    Article  PubMed  CAS  Google Scholar 

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© 1999 Springer-Verlag Italia

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Mercuriali, F., Inghilleri, G. (1999). Albumin: Is It a Play-Maker, a Carrier or Both?. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2145-7_43

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  • DOI: https://doi.org/10.1007/978-88-470-2145-7_43

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0051-3

  • Online ISBN: 978-88-470-2145-7

  • eBook Packages: Springer Book Archive

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