Abstract
Clinical trials, by definition, need to have an aim, an outcome measure. Indeed, there is no point conducting a trial if there is no endpoint in view. The choice of the outcome measure employed will vary according to the agent/technique being assessed but in intensive care medicine, the majority of clinical trials currently focus on the 28 day all-cause mortality rate. This measure may, however, not necessarily be the most appropriate, and we will discuss the reasons for this, and possible alternatives, in this paper.
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References
Petros AJ, Marshall JC, van Saene HKF (1995) Should morbidity replace mortality as an end-point for clinical trials in intensive care? Lancet 345:369–371
Hoffman SL, Punjabi NH, Kumala S et al (1984) Reduction of mortality in chloramphenicol-treated severe typhoid fever by high-dose dexamethasone. N Engl J Med 310:82–88
The veterans administration systemic sepsis cooperative study group (1987) Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. N Engl J Med 317:659–665
Marshall JC, Cook DJ, Christou NV et al (1995) Multiple organ dysfunction score: A reliable descriptor of a complex clinical outcome. Crit Care Med 23:1638–1652
Vincent JL, Moreno R, Takala J et al (1996) The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. Intensive Care Med 22:707–710
Sprung CL, Eidelman LA (1996) Worldwide similarities and differences in the forgoing of life-sustaining treatments. Intensive Care Med 22:1003–1005
Prendergast TJ, Luce JM (1997) Increasing incidence of withholding and withdrawal of life support from the critically ill. Am J Respir Crit Care Med 155:15–20
Decruyenaere J, De Deyne C, Poelaert J, Colardyn F (1995) Morbidity or mortality as end-point for clinical trials in intensive care (letter). Lancet 345:986–987
Sibbald WJ, Vincent JL (1995) Round table conference on clinical trials for the treatment of sepsis. Brussels, March 12–14, 1994. Intensive Care Med 21:184–189
Vincent JL (1997) New therapies in sepsis. Chest 112:S330–S338
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© 1999 Springer-Verlag Italia
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Vincent, JL. (1999). Is Mortality the Only Outcome Measure in ICU Patients?. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2145-7_10
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DOI: https://doi.org/10.1007/978-88-470-2145-7_10
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0051-3
Online ISBN: 978-88-470-2145-7
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