Lymphocyte Trafficking in the Central Nervous System

  • H. Lassmann
Part of the Topics in Neuroscience book series (TOPNEURO)


The central nervous system (CNS) is separated from the peripheral immune system by the blood-brain barrier. This tight barrier system impedes the exchange of cells and inflammatory mediators between the nervous tissue and the blood. Thus, for our understanding of the pathogenesis of brain inflammation, essential questions deal with the mechanisms of normal immune surveillance, the routes and mechanisms by which immune cells are recruited into the brain, how immune cells recognize their specific brain targets, and finally how they are cleared from established lesions during recovery. Basic principles regarding these questions have been recognized during recent years, and these will be discussed in this short review.


Major Histocompatibility Complex Experimental Autoimmune Encephalomyelitis Experimental Allergic Encephalomyelitis Inclusion Body Myositis Brain Inflammation 


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Copyright information

© Springer-Verlag Italia 1999

Authors and Affiliations

  • H. Lassmann
    • 1
  1. 1.Institute of NeurologyUniversity of ViennaViennaAustria

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