Adhesion Receptors Involved in Leukocyte Functions

  • E. Bianchi
  • M. Fabbri
  • R. Pardi
Part of the Topics in Neuroscience book series (TOPNEURO)


Leukocytes are the only nucleated somatic cells that spend a significant portion of their life span displaying a nonadherent, circulating phenotype, being transported by the bloodstream and interstitial fluids towards their sites of action. However, most effector functions of leukocytes depend on and are induced by firm adhesion to other cells or to the extracellular matrix. A logical explanation for this apparent paradox is that while most functional responses of immunocompetent cells are triggered by intimate contacts with other cells, the effective search for potentially harmful environmental agents in a multicellular organism (i.e. immune surveillance) requires continuous patrolling of the body across anatomical barriers. Leukocytes have evolved a highly dynamic and finely regulated adhesive behaviour in order to comply with these contrasting requirements.


Leukocyte Adhesion Adhesion Receptor Leukocyte Function Leukocyte Adhesion Deficiency Leukocyte Transmigration 


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Copyright information

© Springer-Verlag Italia 1999

Authors and Affiliations

  • E. Bianchi
    • 1
  • M. Fabbri
    • 1
  • R. Pardi
    • 1
    • 2
  1. 1.Human Immunology UnitDIBIT-San Raffaele Scientific InstituteMilanItaly
  2. 2.University of Milan School of MedicineMilanItaly

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