Treatment of Inflammatory Demyelinating Polyneuropathy

  • G. Comi
  • L. Roveri
Part of the Topics in Neuroscience book series (TOPNEURO)


The management of acute and chronic inflammatory demyelinating polyneuropathy (Guillain-Barrè syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)) will be the main topic of this chapter. A few comments will also be made about treatment of the demyelinating form of paraproteinaemic demyelinating polyneuropathy (PDN) and of multifocal motor neuropathy (MMN). We will briefly describe the main characteristics of these neuropaties and examines case series and trials which evaluated the principal therapeutic strategies for GBS, CIDP, PDN and MMN, such as intravenous immunoglobulin therapy (IVIg), steroid treatment, plasma exchange, and immunosuppressor administration. Controlled trials demonstrated that IVIg, steroid treatment and plasma exchange are effective in GBS and CIDP. For PDN, the therapeutic strategies are the same as for idiopathic CIDP, but usually the clinical response is poorer. For MMN, IVIg are definitely the first choice treatment.


Plasma Exchange Neurol Neurosurg Psychiatry Monoclonal Gammopathy Chronic Inflammatory Demyelinating Polyneuropathy Multifocal Motor Neuropathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia 1999

Authors and Affiliations

  • G. Comi
    • 1
  • L. Roveri
    • 1
  1. 1.Department of Clinical Neurophysiology, San Raffaele Scientific InstituteUniversity of MilanMilanItaly

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