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From Basic Immunology to Immune-Mediated Demyelination pp 274–286Cite as

Immunopathogenetic Role of Anti-Neural Antibodies in Demyelinating Dysimmune Neuropathies

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Part of the book series: Topics in Neuroscience ((TOPNEURO))

Abstract

Since the original reports by Latov et al. [1] of a patient with a demyelinating neuropathy and IgM antibodies to the myelin-associated glycoprotein [2], antibodies to several other neural antigens have been reported in patients with different forms of dysimmune neuropathies (Table 1). The identification of these reactivities in patients with definite neuropathy syndromes did not only introduce a useful tool in the diagnosis of neuropathies but also cast new light on the immunopathogenetic mechanisms involved. In this chapter, we review evidence supporting possible pathogenetic roles for some of the frequently reported antibody reactivities in demyelinating neuropathies.

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Authors and Affiliations

  1. Giorgio Spagnol Service of Clinical Neuroimmunology, Centro Dino Ferrari, Institute of Clinical Neurology, IRCCS Ospedale Maggiore Policlinico, University of Milan, Via F. Sforza 35, 20122, Milan, Italy

    E. Nobile-Orazio & M. Carpo

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  1. E. Nobile-Orazio
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  2. M. Carpo
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Editors and Affiliations

  1. Department of Neuroscience, S. Raffaele Scientific Institute, Milan, Italy

    Gianvito Martino

  2. Roche Milano Ricerche, Milan, Italy

    Luciano Adorini

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Nobile-Orazio, E., Carpo, M. (1999). Immunopathogenetic Role of Anti-Neural Antibodies in Demyelinating Dysimmune Neuropathies. In: Martino, G., Adorini, L. (eds) From Basic Immunology to Immune-Mediated Demyelination. Topics in Neuroscience. Springer, Milano. https://doi.org/10.1007/978-88-470-2143-3_24

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