Antigen Recognition and Autoimmunity

  • F. Sinigaglia
  • J. Hammer
Part of the Topics in Neuroscience book series (TOPNEURO)


The genes for the human leukocyte antigen (HLA) class II molecules lie within the major histocompatibility complex (MHC) on chromosome 6. The HLA class II loci are clustered into three regions, known as DR, DQ and DP. Each of these regions contains at least one α gene and one ß gene. The gene products form an αß heterodimer which is expressed as a membrane-bound protein on the cell surface. HLA class II proteins play a central role in T-cell selection and activation. They bind peptide fragments derived from protein antigens and display them on the cell surface for interaction with the antigen-specific receptors of T lymphocytes.


Human Leukocyte Antigen Major Histocompatibility Complex Class Myelin Basic Protein Human Leukocyte Antigen Class Experimental Allergic Encephalomyelitis 
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Copyright information

© Springer-Verlag Italia 1999

Authors and Affiliations

  • F. Sinigaglia
    • 1
  • J. Hammer
    • 2
  1. 1.Roche Milano RicercheMilanItaly
  2. 2.Hoffmann-La-Roche Inc.Preclinical R&DNutleyUSA

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