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From Basic Immunology to Immune-Mediated Demyelination pp 195–209Cite as

Magnetic Resonance and Blood-Brain Barrier Dysfunction in Multiple Sclerosis

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Part of the book series: Topics in Neuroscience ((TOPNEURO))

Abstract

Breakdown of the blood-brain barrier (BBB) is an early event in the development of multiple sclerosis (MS) lesions and it is often associated with transvascular inflammatory cell infiltration of the central nervous system (CNS) parenchyma [1]. Because of the frequent association between disruption of the BBB and perivascular lymphocytic infiltration, it has been proposed that BBB damage occurs during the migration of activated T cells into the CNS with the subsequent recognition of antigens and activation of a cascade of cytokine release [2].

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Authors and Affiliations

  1. Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Via Olgettina 60, 20132, Milan, Italy

    M. Rovaris, C. Tortorella & M. Filippi

  2. Division of Neurology and The Scripps Research Institute, Scripps Clinic, La Jolla, California, USA

    J. C. Sipe

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  1. M. Rovaris
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  2. C. Tortorella
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  3. J. C. Sipe
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  4. M. Filippi
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Editors and Affiliations

  1. Department of Neuroscience, S. Raffaele Scientific Institute, Milan, Italy

    Gianvito Martino

  2. Roche Milano Ricerche, Milan, Italy

    Luciano Adorini

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Rovaris, M., Tortorella, C., Sipe, J.C., Filippi, M. (1999). Magnetic Resonance and Blood-Brain Barrier Dysfunction in Multiple Sclerosis. In: Martino, G., Adorini, L. (eds) From Basic Immunology to Immune-Mediated Demyelination. Topics in Neuroscience. Springer, Milano. https://doi.org/10.1007/978-88-470-2143-3_19

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