Abstract
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS) and constitutes a major cause of transient and permanent neurological disability in the adult. The etiology and pathogenesis of MS are only partially understood. On a cellular level, focal mononuclear cell infiltration with demyelination and eventual axonal loss is a crucial pathogenetic event leading to inflammation and subsequent dysfunction. Here we review evidence that adhesion molecules (AM) expressed at the blood-brain barrier (BBB) and on T cells play a central role in immune cell recruitment to the CNS. Therapeutic targeting of AM has been very successful in the corresponding animal model of experimental autoimmune encephalomyelitis and holds promise as a novel treatment strategy to combat human immune-mediated disorders of the CNS.
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© 1999 Springer-Verlag Italia
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Archelos, J.J., Hartung, HP. (1999). Adhesion Molecules and the Blood-Brain Barrier in Multiple Sclerosis. In: Martino, G., Adorini, L. (eds) From Basic Immunology to Immune-Mediated Demyelination. Topics in Neuroscience. Springer, Milano. https://doi.org/10.1007/978-88-470-2143-3_15
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DOI: https://doi.org/10.1007/978-88-470-2143-3_15
Publisher Name: Springer, Milano
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