MHC and Multiple Sclerosis
The major histocompatibility complex (MHC, also called HLA or human leukocyte antigen) and its products have a central role in the immune response. Sharing of the MHC class II region is important for CD4+ (helper) T cell interactions, and sharing of the MHC class I region is important for CD8+ (cytotoxic) T cell interactions. This phenomenon is called MHC restriction of antigen-specific T cell responses.
KeywordsMultiple Sclerosis Multiple Scle Polymorphic Residue Pathogenic Peptide Rare Allele Advantage
Unable to display preview. Download preview PDF.
- 4.Bell JI, Todd JA, McDevitt HO (1989) The molecular basis of HLA disease association. In: Harris H, Hirschorn K (eds) Advances in human genetics. Plenum, London, pp10–17Google Scholar
- 7.Thomson G (1995) Mapping disease genes: family-based association studies. Am J Hum Genet 75: 487–498Google Scholar