MHC and Multiple Sclerosis

  • M. G. Marrosu
Part of the Topics in Neuroscience book series (TOPNEURO)


The major histocompatibility complex (MHC, also called HLA or human leukocyte antigen) and its products have a central role in the immune response. Sharing of the MHC class II region is important for CD4+ (helper) T cell interactions, and sharing of the MHC class I region is important for CD8+ (cytotoxic) T cell interactions. This phenomenon is called MHC restriction of antigen-specific T cell responses.


Multiple Sclerosis Multiple Scle Polymorphic Residue Pathogenic Peptide Rare Allele Advantage 


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Copyright information

© Springer-Verlag Italia 1999

Authors and Affiliations

  • M. G. Marrosu
    • 1
  1. 1.Neurophysiopathology Section, Department of NeuroscienceUniversity of CagliariCagliariItaly

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