Antigen Presentation in the Central Nervous System

  • F. Aloisi
Part of the Topics in Neuroscience book series (TOPNEURO)


Immune-privileged sites such as the central nervous system (CNS), eye and testes, are physiologically adapted to protect their delicate structures and functions from damaging inflammatory responses. Major features contributing to the immune privilege of the CNS include: the blood-brain barrier (BBB) — the tight endothelial junctions of the brain vasculature that limit access of plasma proteins and blood-derived cells to the CNS; the lack of a conventional lymphatic system; the absence within the CNS parenchyma of dendritic cells, the most potent antigen-presenting cells (APC) for initiation of T cell responses; and the paucity of class I and class II major histocompatibility complex (MHC) molecules on resident CNS cells.


Major Histocompatibility Complex Experimental Autoimmune Encephalomyelitis Myelin Basic Protein Major Histocompatibility Complex Molecule Immune Privilege 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia 1999

Authors and Affiliations

  • F. Aloisi
    • 1
  1. 1.Neurophysiology Unit, Laboratory of Organ and System PathophysiologyInstituto Superiore di SanitàRomeItaly

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