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Pacemaker Treatment for Hypertrophic Obstructive Cardiomyopathy: Are Long-Term Results as Good as Short-Term Ones?

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Cardiac Arrhythmias 1999

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Abstract

Hypertrophic cardiomyopathy (HCM) is a complex disease of multiple genetic origins. It is usually a familial cardiac disorder, recognised to be of heterogeneous expression with diverse clinical manifestations and outcome. This structural and functional abnormality of the myocardium is the phenotype of many genetic disorders of encoding proteins of the sarcomere. The diagnostic disorder is a thickened and non-dilated left ventricle in the absence of an associated condition that could explain the hypertrophy.

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References

  1. Maron BJ, Bonow RO, Cannon RO, Leon MB, Epstein SE (1987) Hypertrophie cardiomyopathy: interrelations of clinical manifestations, pathophysiology and therapy. N Engl J Med 316:780–789,844-852

    Article  PubMed  CAS  Google Scholar 

  2. Wigle ED, Sasson Z, Henderson MA et al (1985) Hypertrophic cardiomyopathy: the importance of the site and extent of hypertrophy: a review. Progr Cardiovasc Dis 28:1–83

    Article  CAS  Google Scholar 

  3. Maron B, Gardin J, Flack J, Gidding S, Bild D (1995) Assessment of the prevalence of hypertrophic cardiomyopathy in a general population of young adults: echocardiographic analysis of 4111 subjects in the CARDIA study. Circulation 92:785–789

    Article  PubMed  CAS  Google Scholar 

  4. Maron BJ, Wolfson JK, Epstein SE, Roberts WC (1986) Intramural «small vessel» coronary artery disease in hypertrophic cardiomyopathy. J Am Coll Cardiol 8:545–557

    Article  PubMed  CAS  Google Scholar 

  5. Posma J, Blanksma P, Van der Wall E, Vaalburg W, Crijns H, Lie K (1996) Effects of permanent dual chamber pacing on myocardial perfusion in symptomatic hypertrophic cardiomyopathy. Heart 76:358–362

    Article  PubMed  CAS  Google Scholar 

  6. Frenneaux MP, Counihan PJ, Caforio ALP, Chimakori T, McKenna WJ (1990) Abnormal blood pressure response during exercise in hypertrophic cardiomyopathy. Circulation 82:1995–2002

    Article  PubMed  CAS  Google Scholar 

  7. McKenna W, Camm J (1989) Sudden death in hypertrophic cardiomyopathy. Assessment of patients at high risk. Circulation 80:1489–1492

    CAS  Google Scholar 

  8. Cecchi F, Olivotto I, Montereggi A, Santoro G, Dolara A, Maron BJ (1995) Hypertrophic cardiomyopathy in Tuscany: clinical course and outcome in an unselected regional population. J Am Coll Cardiol 26:1529–1536

    Article  PubMed  CAS  Google Scholar 

  9. Fananapazir L, Chang A, Epstein S, McAreavy D (1992) Prognostic determinants in hypertrophic cardiomyopathy: prospective evaluation of a therapeutic strategy based on clinical, Holter, hemodynamic and electrophysiologic findings. Circulation 85:2149–2161

    Article  PubMed  CAS  Google Scholar 

  10. Harrison DC, Braunwald E, Glick G, Mason DT, Chidsey CA, Ross J Jr (1964) Effects of beta-adrenergic blockade on the circulation, with particular references to observations in patients with hypertrophic subaortic stenosis. Circulation 29:84–98

    Article  PubMed  CAS  Google Scholar 

  11. Hopf R, Kaltenbach M (1987) 10-year results and survival of patients hypertrophic cardiomyopathy treated with calcium-antagonists. Z Kardiol 76[Suppl 3]:137–144

    PubMed  Google Scholar 

  12. Sherrid M, Delia E, Dwyer ED (1988) Oral disopyramid therapy for obstructive hypertrophic cardiomyopathy. Am J Cardiol 62:1085–1088

    Article  PubMed  CAS  Google Scholar 

  13. Ten Berg JM, Suttorp MJ, Knaepen PJ, Ernst S, Vermeulen FEE, Jaarsma W (1994) Hypertrophic obstructive cardiomyopathy: initial results and long-term follow up after narrow septal myectomy. Circulation 90:1781–1785

    Article  PubMed  Google Scholar 

  14. Seiler C, Hess OM, Schoenbeck M et al (1991) Long-term follow up of medical versus surgical therapy for hypertrophic cardiomyopathy: a retrospective study. J Am Coll Cardiol 17:634–642

    Article  PubMed  CAS  Google Scholar 

  15. Sigwart U (1995) Non-surgical myocardial reduction for hypertrophic obstructive cardiomyopathy. Lancet 346:211–213

    Article  PubMed  CAS  Google Scholar 

  16. Hassenstein P, Wolter HH (1967) Therapeutische Beherrschung einer bedrohlichen Situation bei der idiopathischen hypertrophischen Subaortenstenose. Verh Dtsch Ges Kreisl 33:242–246

    CAS  Google Scholar 

  17. Page A, Boudaut R, Bemurat M, Clementy J, Levy S, Besse P (1979) Importance of sequential atrioventricular pacing in obstructive myocardiopathy with atrioventricular block. Arch Mal Coeur 72:1253–1258

    PubMed  CAS  Google Scholar 

  18. Jeanrenaud X, Goy JJ, Kappenberger L (1992) Effects of dual-chamber pacing in hypertrophic obstructive cardiomyopathy. Lancet 339:1318–1323

    Article  PubMed  CAS  Google Scholar 

  19. Fananapazir L, Epstein ND, Curiel RV et al (1994) Longterm results of dual-chamber (DDD) pacing in obstructive hypertrophic cardiomyopathy. Evidence for progressive symptomatic and hemodynamic improvement and reduction of left ventricular hypertrophy. Circulation 90:2731–2742

    CAS  Google Scholar 

  20. Prinzen FW, Augustijn CH, Arts T, Allessi MA, Reneman RS (1990) Redistribution of myocardial fiber strain and blood flow by asynchronous activation. Am J Physiol 258:H300–H308

    Google Scholar 

  21. Kappenberger L, Grobéty M , Jeanrenaud X (1998) The features of a paced heart beat. In: Vardas PE (ed) Cardiac arrhythmias, pacing and electrophysiology. Kluwer, UK, pp 331–336

    Chapter  Google Scholar 

  22. Kappenberger L, Linde C, Daubert C, McKenna W, Meisel E, Sadoul N, Chojinowska L, Guize L, Gras D, Jeanrenaud X, Ryden L (1997) Pacing in hypertrophic obstructive cardiomyopathy, the PIC trial. Eur Heart J 21:1249–1256

    Article  Google Scholar 

  23. Undén A, Schenck-Gustavsson K, Axelson P (1993) Positive effects of increased nurse support for male patients after acute myocardial infarction. Qual Life Res 2:121–127

    Article  PubMed  Google Scholar 

  24. Gadler F, Linde C, Juhlin-Dannfelt A, Ribeiro A, Ryden L (1997) Longterm effects of pacing in patients with hypertrophic cardiomyopathy without outflow tract obstruction at rest. Eur Heart J 18:636–642

    Article  PubMed  CAS  Google Scholar 

  25. Kappenberger LJ, Linde C, Jeanreanud X, Daubert C, McKenna W, Meisel E, Sadoul N, Chojnowska L, Guize L, Gras D, Aebischer N, Gadler F, Rydén L, and the Pacing in Cardiomyopathy (PIC) Study Group (1999) Clinical progress after randomized on/off pacemaker treatment for hypertrophic obstructive cardiomyopathy. Europace 1999; 1:77–84

    Article  CAS  Google Scholar 

  26. Nishimura RA, Trusty JM, Hayes DL et al (1997) Dual-chamber pacing for patients with hypertrophic cardiomyopathy: a prospective randomized double-blind crossover trial (abstract). J Am Coll Cardiol 29:435–441

    Article  PubMed  CAS  Google Scholar 

  27. Maron B, Nishimura R, McKenna W (1999) The M-Pathy study investigators assessment of permanent dual-chamber pacing as a treatment for drug-refractory symptomatic patients with obstructive hypertrophic cardiomyopathy. Circulation 99:2927–2933

    Article  PubMed  CAS  Google Scholar 

  28. Wigle ED, Rakowsky H, Kimball BP, Williams WG (1995) Hypertrophic cardiomyopathy, clinical spectrum and treatment. Circulation 92:1680–1692

    Article  PubMed  CAS  Google Scholar 

  29. Knight C, Kurbaan A, Seggewiss H, Henein M, Gunning M, Harrington D, Fassbender D, Gleichmann U, Sigwart U (1997) Nonsurgical septal reduction for hypertrophic obstructive cardiomyopathy. Circulation 95:2075–2081

    Article  PubMed  CAS  Google Scholar 

  30. Prinzen FW, Augustijn CH, Allessie MA et al (1992) The time sequence of electrical and mechanical activation during spontaneous beating and ectopic stimulation. Eur Heart J 13:535–543

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Cardiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland

    L. J. Kappenberger, N. Aebischer & X. Jeanrenaud

Authors
  1. L. J. Kappenberger
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  2. N. Aebischer
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  3. X. Jeanrenaud
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Editor information

Editors and Affiliations

  1. Divisione di Cardiologia, Ospedale Umberto I, Via Circonvallazione 50, I-30174, Venezia Mestre, Italy

    Antonio Raviele MD

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Kappenberger, L.J., Aebischer, N., Jeanrenaud, X. (2000). Pacemaker Treatment for Hypertrophic Obstructive Cardiomyopathy: Are Long-Term Results as Good as Short-Term Ones?. In: Raviele, A. (eds) Cardiac Arrhythmias 1999. Springer, Milano. https://doi.org/10.1007/978-88-470-2139-6_69

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  • DOI: https://doi.org/10.1007/978-88-470-2139-6_69

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2178-5

  • Online ISBN: 978-88-470-2139-6

  • eBook Packages: Springer Book Archive

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