Midodrine for Treatment of Vasovagal Syncope
Most vasovagal fainters who seek medical attention require no more than the reassurance that their physician understands the basis of their symptoms, and education regarding both the nature of the problem and techniques which may avert recurrences. However, when spells are frequent, or are associated with physical injury, or threaten to compromise occupational status, prophylactic treatment measures become a consideration. Unfortunately, the optimum treatment approach remains uncertain.
KeywordsCardiac Pace Vasovagal Syncope Unexplained Syncope Neurocardiogenic Syncope Upright Tilt
Unable to display preview. Download preview PDF.
- 2.Fitzpatrick AP, Ahmed R, Williams S, Sutton R (1991) A randomised trial of medical therapy in “malignant vasovagal syndrome” or “neurally-mediated bradycardia hypotension syndrome”. Eur J Cardiac Pacing Electrophysiol 2:99–102Google Scholar
- 7.Kosinski DJ, Grubb BP, Temesy-Armos PN (1994) The use of serotonin re-uptake inhibitors in the treatment of neurally mediated cardiovascular disorders. J Serotonin Res 1:85–90Google Scholar
- 9.Sutton R, Brignole M, Raviele A, for the Vasis Group Investigators (1998) Randomised controlled trial of etilefrine therapy for vasovagal syncope. Arch Mal Coeur 91 (special III):242 (abstr)Google Scholar
- 10.Moya A, Permanyer-Miralda G, Sagrista-Sauleda J, Carne X, Rius T, Mont L, Soler Soler J (1995) Limitations of head-up tilt test for evaluating the efficacy of therapeutic interventions in patients with vasovagal syncope: results of a controlled study of etilefrine versus placebo. J Am Coll Cardiol 25:65–69PubMedCrossRefGoogle Scholar
- 16.Raviele A, Themistoclakis S, Gasparini G (1996) Drug treatment of vasovagal syncope. In: Blanc JJ, Benditt DG, Sutton R (eds) Neurally-mediated syncope: pathophysiology, investigations, and treatment. Futura, Armonk, NY, pp 113–117Google Scholar
- 17.Vasovagal Syncope International Study (VASIS) Group (1993) Double-blind randomised study of etilefrine versus placebo in patients with tilt-induced recurrent vasovagal syncope. Eur J Cardiac Pacing Electrophysiol 3:64Google Scholar
- 19.Anonymous (1996) Midodrine hydrochloride: clinical investigator’s brochure. Roberts Pharmaceutical CorpGoogle Scholar
- 25.Benditt DG, Samniah N, Sakaguchi S, Fahy G, Wilbert L (1998) Midodrine is effective in patients with refractory neurally-mediated syncope. Circulation 98[Suppl I]:706 (abstr)Google Scholar