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Adenosine-Sensitive Syncope: Does it Really Exist?

  • C. Menozzi
  • M. Brignole
  • G. Gaggioli
  • A. Del Rosso
  • S. Costa
  • A. Bartoletti
  • N. Bottoni
  • G. Lolli
Conference paper

Abstract

Adenosine-sensitive syncope has recently been identified as a cause of syncope in some patients affected by unexplained syncope who have an abnormal response to adenosine triphosphate (ATP) test and a negative work-up after complete conventional investigations [1]. Some authors [2–4] have hypothesized that adenosine could be an important modulator in triggering a vasovagal response in susceptible patients. Indeed, the injection of a bolus of adenosine during head-up tilt testing (HUT) has been seen to provoke a vasovagal response in susceptible patients with syncope with a positivity rate comparable to that of isoproterenol [2, 3]. The ATP test has been suggested as a useful tool to identify a subgroup of patients at high risk of severe cardioinhibitory responses of vagal origin [4]. In a recent study [5], we evaluated the possible relationship between adenosine-sensitive syncope and tilt-induced vasovagal syncope. For this purpose, we performed both the ATP and HUT tests in a group of consecutive patients with syncope of uncertain origin, and compared the clinical characteristics of the patients who had a positive response to one or both tests.

Keywords

Adenosine Triphosphate Atrioventricular Block Vasovagal Syncope Syncopic Episode Sinus Arrest 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia 2000

Authors and Affiliations

  • C. Menozzi
    • 1
  • M. Brignole
    • 2
  • G. Gaggioli
    • 2
  • A. Del Rosso
    • 3
  • S. Costa
    • 2
  • A. Bartoletti
    • 2
  • N. Bottoni
    • 1
  • G. Lolli
    • 1
  1. 1.Sezione di AritmologiaOspedale S. Maria NuovaReggio EmiliaItaly
  2. 2.Sezione di AritmologiaOspedali RiunitiLavagnaItaly
  3. 3.Reparto di CardiologiaOspedale S. Pietro IgneoFucecchioItaly

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