Gene Therapy for Long QT Syndrome: Fact or Fiction?
For many years the therapy for long QT syndrome (LQTS) has been based on simple and sound principles [1, 2]. In essence, therapy had been guided by the time-honored concept that it has to reflect understanding of the mechanisms, underlying or precipitating the main symptoms. In those happy days things were simple, we thought that we were dealing with one disease, and we were assuming that the precipitating events were more or less the same for all patients; the gen- erally accepted common pathway for the initiation of the life-threatening arrhythmias of LQTS was represented by a sudden neural release of norepineph- rine secondary to an abrupt activation of the sympathetic nervous system .
KeywordsBrugada Syndrome Sympathetic Denervation Sodium Channel Gene Cardiac Sympathetic Denervation Left Cardiac Sympathetic Denervation
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