How Common Is a Genetic Origin of Atrial Fibrillation?

  • R. Brugada
  • J. Brugada
  • R. Roberts
Conference paper


Few disciplines will have the impact of molecular genetics. Cardiology has benefited from its techniques and, since 1989, with the discovery of the first chromosomal locus for a cardiac disease, multiple disease-causing genes have been discovered. The field is progressing rapidly, and it is certain that in the coming years genetics will play a role not only in diagnostics, but in prevention and treatment of these inherited diseases. Arrhythmias, like most diseases, result from an interaction of environmental and genetic factors. In the last few decades we have acquired extensive knowledge about environmental factors triggering arrhythmias. The role of genetics has been described at all levels of the conduction system of the heart by the documentation of families with several individuals suffering from an inherited form of arrhythmia. However, it has not been until this last decade, with the introduction of molecular biology and the techniques of genetic mapping, that we have been able to study these families and identify the genes that cause their disease.


Atrial Fibrillation Bacterial Artificial Chromosome Hypertrophic Cardiomyopathy Genetic Origin Candidate Gene Approach 
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  1. 1.
    Feinberg WM, Blackshear JL, Laupacis A, Kronmal R, Hart RG (1995) Prevalence, age distribution, and gender of patients with atrial fibrillation. Arch Intern Med 155:469–473PubMedCrossRefGoogle Scholar
  2. 2.
    Albers GW (1994) Atrial fibrillation and stroke: three new studies, three remaining questions. Arch Intern Med 154:1443–1448PubMedCrossRefGoogle Scholar
  3. 3.
    Wolff L (1943) Familial auricular fibrillation. N Engl J Med 229:396–397CrossRefGoogle Scholar
  4. 4.
    Girona J, Domingo A, Albert D, Casaldaliga J, Mont L, Brugada J (1997) Fibrilación auricular familiar. Rev Esp Cardiol 50:548–551PubMedGoogle Scholar
  5. 5.
    Brugada R, Tapscott T, Czernuszewicz GZ, Marian AJ, Iglesias A, Mont L, Brugada J, Girona J, Domingo A, Bachinski LL, Roberts R (1997) Identification of a genetic locus for familial atrial fibrillation. N Engl J Med 336:905–911PubMedCrossRefGoogle Scholar
  6. 6.
    Brugada R, Bachinski LL, Hill R, Roberts R (1998) Familial atrial fibrillation is a genetically heterogeneous disease. J Am Coll Cardiol 31:349A (abstr)Google Scholar

Copyright information

© Springer-Verlag Italia 2000

Authors and Affiliations

  • R. Brugada
    • 1
  • J. Brugada
    • 2
  • R. Roberts
    • 1
  1. 1.Department of CardiologyBaylor College of MedicineHoustonUSA
  2. 2.Cardiovascular Institute, Hospital ClinicUniversity of BarcelonaSpain

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