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Effect of β-Blocker Therapy on the Frequency and Type of Cardiac Events in Patients with the Hereditary Long QT Syndrome

  • A. J. Moss
  • W. Zareba
  • W. J. Hall
  • J. L. Robinson
  • M. L. Andrews
Conference paper

Abstract

The hereditary long QT syndrome (LQTS) is a genetic channelopathy in which affected individuals have prolonged ventricular repolarization, frequent syncopal episodes, and a propensity to sudden arrhythmic cardiac death [1, 2]. β-Blocker therapy is the recommended treatment of choice for this disorder, although other forms of therapy are also used including pacemakers to prevent bradycardia- induced ventricular tachyarrhythmias [3], surgical antiadrenergic therapy with left cervico-thoracic sympathetic ganglionectomy [4], and implantable car- dioverter defibrillators [5] in patients refractory to β-blocker therapy.

Keywords

Cardiac Event Affect Family Member Blocker Therapy Blocker Treatment Implantable Cardioverter Defibrillator Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Moss AJ, Schwartz PJ, Crampton RS, Locati E, Carleen E (1985) The long QT syndro-me: a prospective international study. Circulation 71:17–21PubMedCrossRefGoogle Scholar
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    Moss AJ, Schwartz PJ, Crampton RS, Tzivoni D, Locati EH, MacCluer J, Hall WJ, Weitkamp L, Vincent M, Garson A Jr, Robinson JL, Benhorin J, Choi S (1991) The long QT syndrome: prospective longitudinal study of 328 families. Circulation 84:1136– 1144PubMedCrossRefGoogle Scholar
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    Moss AJ, Liu JE, Gottlieb S, Locati E, Schwartz PJ, Robinson JL (1991) Efficacy of per-manent pacing in the management of high-risk patients with long QT syndrome. Circulation 84:1524–1529PubMedCrossRefGoogle Scholar
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    Schwartz PJ, Locati E, Moss AJ, Crampton RS, Trazzi R, Ruberti U (1991) Left cardiac sympathetic denervation in the therapy of the congenital long QT syndrome: a worldwide report. Circulation 84:503–511PubMedCrossRefGoogle Scholar
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    Priori SG, Zareba WJ, Napolitano C, Locati EH, Robinson JL, Diehl L, Schwartz PJ, Moss AJ (1996) The implantable cardioverter defibrillator (ICD) in the long QT syn-drome: data from the international registry. Pacing Clin Electrophysiol 19(2):556Google Scholar
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    Vincent GM, Fox J, Zhang L, Timothy KW (1996) Beta-blockers markedly reduce risk and syncope in KVLQT1 long QT patients. Circulation 94:I–204Google Scholar

Copyright information

© Springer-Verlag Italia 2000

Authors and Affiliations

  • A. J. Moss
    • 1
  • W. Zareba
    • 1
  • W. J. Hall
    • 2
  • J. L. Robinson
    • 3
  • M. L. Andrews
    • 3
  1. 1.Departments of MedicineUniversity of Rochester School of Medicine and DentistryRochesterUSA
  2. 2.Departments of BiostatisticsUniversity of Rochester School of Medicine and DentistryRochesterUSA
  3. 3.Departments of Community and Preventive MedicineUniversity of Rochester School of Medicine and DentistryRochesterUSA

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