The Syndrome of Right Bundle Branch Block, ST Segment Elevation in V1 to V3 and Sudden Death. Are Asymptomatic Patients at High Risk for Sudden Death?
In 1992 a new syndrome consisting of syncopal episodes and/or sudden death in patients with a structurally normal heart and a characteristic electrocardiogram (ECG) with a pattern of right bundle branch block with an ST segment elevation in leads VI to V3 was described . In 1998 the poor prognosis of patients with this syndrome who were not receiving an implantable defibrillator was reported [2,3]. In 1998 the genetic nature of the disease and its association with a mutation in the cardiac sodium channel gene was described . Because the diagnosis is easily made by means of the ECG, an increasing number of asymptomatic patients with the ECG pattern are being identified worldwide. This fact has raised the question of whether the presence of an abnormal ECG without symptoms indicates that the patient is affected by the disease and what the prognosis is. In this article we will review our present knowledge concerning asymptomatic patients with the classical ECG pattern of the disease.
KeywordsSudden Death Antiarrhythmic Drug Asymptomatic Individual Brugada Syndrome Right Bundle Branch Block
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